Actively Recruiting
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
Led by Massachusetts General Hospital · Updated on 2025-05-14
60
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.
CONDITIONS
Official Title
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 45 years old
- Fluent in English
- Able to give informed consent
- For adults with schizophrenia: confirmed DSM-V diagnosis of schizophrenia
- For adults with schizophrenia: unmedicated or on a stable dose of antipsychotic drugs
You will not qualify if you...
- Ferrous metal in the body
- Currently pregnant or breastfeeding
- Motor problems preventing finger tapping task
- IQ less than 85
- Other neurological disorders including seizure disorders
- Significant hearing or vision loss
- Chronic medical conditions affecting sleep
- Unstable chronic medical conditions such as asthma, diabetes, cystic fibrosis, or cardiac disease
- Diagnosed sleep disorder other than insomnia
- History of head injury with prolonged unconsciousness or neurological effects
- For healthy adults: history of mental illness
- For healthy adults: current use of psychotropic medications or medications affecting sleep or cognition
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Charlestown, Massachusetts, United States, 02129
Actively Recruiting
Research Team
L
Lindsey Jones, MS
CONTACT
D
Dara Manoach, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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