Actively Recruiting
Effects of Beverage Volume, Glycerol Concentration, and Sodium Concentration on Fluid Balance in Healthy Euhydrated Men and Women at Rest
Led by PepsiCo Global R&D · Updated on 2025-07-17
80
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how different levels of sodium and glycerol in beverages, along with varying drink volumes, affect fluid balance in healthy adults who are well hydrated. The study aims to understand how these ingredients help the body keep fluids by reducing urine loss, which is important for maintaining overall body hydration. This research involves healthy men and women aged 18 to 50, who are generally physically active. Participants will consume different types of beverages that vary in electrolyte and glycerol content and volume, including a placebo beverage without electrolytes or glycerol. Each beverage is taken in three doses over 35 minutes, followed by a 25-minute rest period before measurements begin. The study includes multiple experimental beverage groups to compare how these factors influence fluid retention. During the study, participants will undergo repeated assessments over 210 minutes after drinking, including measurements of fluid balance, urine volume and concentration, blood markers like electrolytes and glucose, heart rate, and blood pressure. Participants will also report any gastrointestinal discomfort or headaches. Safety is monitored throughout the study, and menstrual cycle information is collected at screening. The trial runs until December 2025 and involves detailed monitoring of how beverages affect body hydration over time.
CONDITIONS
Brief Title
Effects of Beverage Volume, Glycerol Concentration, and Sodium Concentration on Fluid Balance in Healthy Euhydrated Men and Women at Rest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Female participants must not be pregnant
- Age between 18 and 50 years, inclusive
- Recreationally active with light to moderate exercise at least 3 days per week for 30 minutes each
- Non-smoker or quit smoking at least 6 months ago
- Not taking medications that interfere with the study such as diuretics
- No health conditions like cardiovascular, renal, or metabolic diseases that interfere with the study
- Willing to avoid alcohol 24 hours before visits
- Willing to fast overnight for about 8-12 hours
- Willing to avoid vigorous exercise for 24 hours before visits
- Willing to eat the same food the day before each visit
- Provide written consent to participate
You will not qualify if you...
- Participated in any clinical trial within past 30 days
- Participated in any PepsiCo trial within past 6 months
- Has a condition or takes medication that may affect consent, study compliance, result interpretation, or safety
- Employed by or closely related to someone employed by a company competing with Gatorade, unless disclosed and approved
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 6 separate beverage testing days
Participants consume different beverages with varying volumes and concentrations of glycerol and sodium, followed by rest and fluid balance assessments.
6 visits (in-person) for beverage testing
Trial Site Locations
Total: 3 locations
1
IMG Academy/GSSI Bradenton Gatorade Sports Science Institute
Bradenton, Florida, United States, 34210
Actively Recruiting
2
GCP Research
St. Petersburg, Florida, United States, 33705
Actively Recruiting
3
Gatorade Sports Science Institute
Valhalla, New York, United States, 10595
Actively Recruiting
Research Team
L
Lindsay Baker, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
10
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