Actively Recruiting
Resting Indicators of Vascular Health and Cardiovascular Reactivity in Females With Normal-Weight Obesity
Led by Ball State University · Updated on 2026-04-24
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying vascular health in females with a normal body mass index (BMI) to understand how differences in body fat and muscle mass affect cardiovascular disease risk. This study focuses on females aged 18 to 50 who have a healthy BMI but may have varying body compositions. The goal is to evaluate resting vascular indicators and cardiovascular response to stress in this group. Participants will complete two separate study visits in a randomized order. During the high-fat meal trial, participants will fast, then consume two Jimmy Dean breakfast bowls high in fat, while vascular measurements and blood samples will be taken at baseline and multiple times after the meal. In the stress trial, participants will fast and then undergo a mental stress task, with vascular measurements and blood samples collected before and after the stress. Blood tests will measure factors like cholesterol, triglycerides, inflammatory markers, and epinephrine. Throughout the study, participants will have vascular assessments including flow-mediated dilation, pulse wave analysis, and pulse wave velocity. Blood will be drawn multiple times to analyze serum markers related to cardiovascular health and inflammation. Each vascular measurement requires resting quietly in a supine position. The study involves two main visits with detailed monitoring before and after interventions, and all data will be collected up to one year for ongoing analysis.
CONDITIONS
Brief Title
Effects of Body Composition on Vascular Health in Females With a Healthy Body Weight
Who Can Participate
Eligibility Criteria
You may qualify if you...
- You are 18 to 50 years old
- Your biological sex is female
- Your BMI is in the normal range (18.5-24.9 kg/m2)
- You are not pregnant or expecting to become pregnant
- You are not postmenopausal
- You have not been diagnosed with cardiometabolic conditions such as cardiovascular disease or type 2 diabetes
- You have not been diagnosed with chronic inflammatory conditions like rheumatoid arthritis or inflammatory bowel disease
- You do not regularly take anti-inflammatory drugs more than twice per week or can temporarily stop using them
- You do not use lipid-lowering drugs, glucose-lowering drugs, tobacco products, or illicit drugs
- You do not have a pacemaker
- You do not have dietary restrictions that prevent you from eating the provided meal (e.g., vegan, vegetarian, gluten-free, or relevant food allergies)
- You are able to lie down in a quiet, dark area for at least 10 minutes
You will not qualify if you...
- You are not between 18 and 50 years old
- Your biological sex is not female
- Your BMI is outside the normal range (not 18.5-24.9 kg/m2)
- You are pregnant or expecting to become pregnant
- You are postmenopausal
- You have been diagnosed with cardiometabolic conditions such as cardiovascular disease or type 2 diabetes
- You have been diagnosed with chronic inflammatory conditions like rheumatoid arthritis or inflammatory bowel disease
- You regularly take anti-inflammatory drugs more than twice per week or cannot suspend their use temporarily
- You use lipid-lowering drugs, glucose-lowering drugs, tobacco products, or illicit drugs
- You have a pacemaker
- You have dietary restrictions that prevent you from eating the provided meal (e.g., vegan, vegetarian, gluten-free, or relevant food allergies)
- You are unable to lie down in a quiet, dark area for at least 10 minutes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day
Participants will report fasted, have an intravenous catheter inserted, and baseline blood sample collected. Vascular measurements will be performed before and after consuming a high-fat meal. Blood samples will be collected multiple times up to 4 hours after the meal to assess various markers.
1 visit (in-person)
Duration - Single day
Participants will report fasted, have an intravenous catheter inserted, and baseline blood sample collected. Vascular measurements will be performed before and after undergoing a mental stress task. Blood samples will be collected multiple times up to 90 minutes after the stress task to assess various markers.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Ball State University- Nutrition Assessment Lab
Muncie, Indiana, United States, 47303
Actively Recruiting
Research Team
B
Bryant H Keirns, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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