Study of Vascular Health and Stress Response in Women with Normal BMI Impact of Body Fat and Muscle on Heart and Blood Vessel Function

What this Trial Is About

Researchers are studying vascular health in females with a normal body mass index BMI to understand how differences in body fat and muscle mass affect cardiovascular disease risk. This study focuses on females aged 18 to 50 who have a healthy BMI but may have varying body compositions. The goal is to evaluate resting vascular indicators and cardiovascular response to stress in this group. Participants will complete two separate study visits in a randomized order. During the high-fat meal trial, participants will fast, then consume two Jimmy Dean breakfast bowls high in fat, while vascular measurements and blood samples will be taken at baseline and multiple times after the meal. In the stress trial, participants will fast and then undergo a mental stress task, with vascular measurements and blood samples collected before and after the stress. Blood tests will measure factors like cholesterol, triglycerides, inflammatory markers, and epinephrine. Throughout the study, participants will have vascular assessments including flow-mediated dilation, pulse wave analysis, and pulse wave velocity. Blood will be drawn multiple times to analyze serum markers related to cardiovascular health and inflammation. Each vascular measurement requires resting quietly in a supine position. The study involves two main visits with detailed monitoring before and after interventions, and all data will be collected up to one year for ongoing analysis.

Effects of Body Composition on Vascular Health in Females With a Healthy Body Weight