Actively Recruiting
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Led by Spaulding Rehabilitation Hospital · Updated on 2026-03-20
44
Participants Needed
1
Research Sites
682 weeks
Total Duration
On this page
Sponsors
S
Spaulding Rehabilitation Hospital
Lead Sponsor
F
Foundation Wings For Life
Collaborating Sponsor
AI-Summary
What this Trial Is About
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand the mechanisms by which intermittent hypoxia enhances motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.
CONDITIONS
Official Title
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years
- Medical clearance to participate
- Spinal cord injury lesion at or below C2 and above T12 with non-progressive cause
- Motor-incomplete classification with visible voluntary leg movement
- Injury duration longer than 1 year
You will not qualify if you...
- Severe medical illnesses such as infection, cardiovascular disease, ossification, recurrent autonomic dysreflexia, unhealed wounds, or history of pulmonary complications
- Pregnant women
- History of seizures, brain injury, or epilepsy
- Currently receiving physical therapy
- Diabetes
- Cirrhosis
- Allergies or intolerance to caffeine or NSAIDs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Spaulding Rehabilitation Hospital
Cambridge, Massachusetts, United States, 02138
Actively Recruiting
Research Team
R
Randy D Trumbower, PT, PhD
CONTACT
S
Stella Barth, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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