Actively Recruiting
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
Led by Embry-Riddle Aeronautical University · Updated on 2025-10-15
80
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.
CONDITIONS
Official Title
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults between 18 and 40 years old
- Recreationally active, performing at least 3 hours of structured physical activity per week
- Non-smokers for at least the past 6 months
- No known cardiovascular, pulmonary, metabolic, or neuromuscular disease
- Able to perform cycle ergometer exercise to volitional fatigue
- Willing to avoid high-nitrate foods and supplements for 48 hours before each testing session
- Able and willing to provide written informed consent and follow study procedures
You will not qualify if you...
- History or diagnosis of heart disease, hypertension, diabetes, or chronic respiratory disorders
- Current use of medications or supplements affecting cardiovascular, metabolic, or respiratory function
- Smoking, vaping, or tobacco use within the past 6 months
- Known allergy or intolerance to beetroot products or nitrates
- Participation in another interventional research study within the past 30 days
- Pregnant or breastfeeding women
- Orthopedic or musculoskeletal limitations preventing safe exercise testing
- Inability to meet inclusion criteria or complete baseline testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Embry-Riddle Aeronautical University
Daytona Beach, Florida, United States, 32114
Actively Recruiting
Research Team
S
Scott Ferguson K Ferguson, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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