Actively Recruiting
Effects of Cannabidiol on Stress and Nicotine Withdrawal
Led by Johns Hopkins University · Updated on 2025-09-02
90
Participants Needed
1
Research Sites
209 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between these types of stress. Participants will be administered CBD and exposed to stress. Biological and subjective measures will be collected. Participants may be asked to stop use for 24 hours. Researchers will also investigate withdrawal effects between participants who have not smoked nicotine in 24 hours and those who have continued to smoke before each session.
CONDITIONS
Official Title
Effects of Cannabidiol on Stress and Nicotine Withdrawal
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 21 to 70 years inclusive
- Use more than 5 cigarettes per day for over 2 years
- Confirm cigarette use with expired carbon monoxide level over 8 ppm
- Consume less than 2 alcoholic drinks per day on average (less than 14 drinks per week)
- Maintain a normal nighttime sleep schedule without graveyard or third shift work
- Willingness to use effective contraception during the study and for 30 days after last dose if applicable
You will not qualify if you...
- Intention to reduce or quit cannabis or tobacco use within the next 30 days
- Diagnosis of substance use disorder (other than alcohol, cannabis, or nicotine) according to DSM-5
- Positive test for illicit drugs other than cannabis
- Positive breath alcohol test above 0.01 g/210L at study admission
- Current physical or mental illness or medication affecting safety or study integrity
- Resting heart rate over 100 bpm, systolic blood pressure over 160 mmHg or under 100 mmHg, or diastolic blood pressure over 100 mmHg or under 50 mmHg
- Cold intolerance or medical conditions worsened by cold exposure
- Current pregnancy, planning pregnancy within 3 months, or breastfeeding
- History or current significant cardiac arrhythmias or vasospastic disease
- History of or current liver disease or elevated liver enzymes above specified limits
- Participation in another clinical trial or receipt of study drug within 30 days prior to enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Behavioral Pharmacology Research Unit
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
L
Lauren Brogdon, MHS
CONTACT
D
Dustin C. Lee, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here