Actively Recruiting

Age: 18Years - 90Years
All Genders
ID06098300

Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension - a Pilot Study

Led by Medical University of Vienna · Updated on 2024-09-19

30

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating whether structural and functional changes in the retina and choroid remain after patients with initially poorly-controlled arterial hypertension achieve well-controlled blood pressure. The study focuses on retinal capillary density and oxygen metabolism using advanced imaging techniques. This observational pilot study aims to better understand how blood pressure management affects eye microcirculation in people with hypertension. The study uses Optical Coherence Tomography Angiography (OCT-A) to non-invasively assess retinal microvasculature changes. It will also examine retinal oxygen metabolism and choroidal blood flow through various imaging methods. The main focus is to observe changes after 12 weeks of achieving blood pressure targets with antihypertensive medication, without introducing new treatments as it is observational. Participants will undergo regular blood pressure self-measurements and document these values in a diary. Researchers will assess changes in retinal vessel density, choroidal vascularity, neurovascular coupling, retinal oxygen saturation, ocular blood flow, and retinal vessel diameter after 12 weeks. The study involves eye exams and monitoring of blood pressure control to evaluate vascular changes related to hypertension management over this period.

CONDITIONS

Brief Title

Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension

Who Can Participate

Age: 18Years - 90Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Men and women aged 18 years or older
  • Signed informed consent
  • Normal eye exam except for hypertensive retinopathy
  • Non-smokers
  • Diagnosed or pre-existing mild to moderate primary arterial hypertension with systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg
  • Planned start or adjustment of antihypertensive medication by cardiology
  • Agreement to regularly measure and record blood pressure in a diary
Not Eligible

You will not qualify if you...

  • Participation in another clinical trial within 3 weeks before this study
  • Blood donation within 3 weeks before the study
  • Symptoms of significant illness within 3 weeks before the study
  • Personal or family history of epilepsy
  • Secondary hypertension causes (e.g., hyperaldosteronism, pheochromocytoma, renal artery stenosis, renal diseases, Cushing syndrome, coarctation of the aorta)
  • History of hypertensive encephalopathy or brain bleeding
  • Diabetes mellitus type 1 or 2
  • Pregnant or breastfeeding women
  • Women of childbearing potential not using effective contraception (if not menopausal, hysterectomized, or sterilized)

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Monitoring

Duration - 12 weeks

Participants are observed while achieving blood pressure treatment targets with antihypertensive medication. Changes in retinal capillary density and ocular blood flow are assessed.

1 baseline visit and 1 follow-up visit

Trial Site Locations

Total: 1 location

1

Medical University of Vienna

Vienna, Austria, 1090

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Research Team

G

Gerhard Garhöfer, Assoc. Prof. Priv. Doz. MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Worldwide Trends in Prevalence, Mortality, and Disability-Adjusted Life Years for Hypertensive Heart Disease From 1990 to 2017.

Haijiang Dai, Nicola Luigi Bragazzi, Arwa Younis...

https://pubmed.ncbi.nlm.nih.gov/33583201

2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension.

Bryan Williams, Giuseppe Mancia, Wilko Spiering...

https://pubmed.ncbi.nlm.nih.gov/30234752

Impact of Arterial Hypertension on the Eye: A Review of the Pathogenesis, Diagnostic Methods, and Treatment of Hypertensive Retinopathy.

Jacek Dziedziak, Anna Zaleska-Żmijewska, Jacek Paweł Szaflik...

https://pubmed.ncbi.nlm.nih.gov/35046380

Hypertension-Mediated Organ Damage and Long-term Cardiovascular Outcomes in Asian Hypertensive Patients without Prior Cardiovascular Disease.

Jung Sun Oh, Chang Hoon Lee, Joong Il Park...

https://pubmed.ncbi.nlm.nih.gov/33316856

Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography.

Jacqueline Chua, Calvin Woon Loong Chin, Jimmy Hong...

https://pubmed.ncbi.nlm.nih.gov/30113530