Actively Recruiting
Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients & Non-Cancer Control Subjects With Optional Sub-Study Research Brain MRI
Led by University of Rochester · Updated on 2026-04-24
150
Participants Needed
1
Research Sites
544 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study is enrolling newly diagnosed breast cancer patients about to start chemotherapy and age-matched control participants. The investigator is trying to better understand the prevalence of cognitive difficulties in cancer patients receiving chemotherapy compared to the general population as well as what biological mechanisms may play a role in the development of these difficulties. Patients will be asked to complete six assessments over the course of approximately 5 months. Assessments 1,3, 4.5 and 5 include computerized and paper and pencil cognitive testing as well as blood draws. Assessments 2 and 4 only involve the collection of a blood sample. An optional sub study is offered after Assessment 1. It involves a research brain MRI at Assessment 4.5 and cognitive testing and another research brain MRI at Assessment 6.
CONDITIONS
Official Title
Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients & Non-Cancer Control Subjects With Optional Sub-Study Research Brain MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female with invasive non-metastatic breast cancer (stage I-IIIC)
- Scheduled to start chemotherapy with Adriamycin and Cytoxan
- No prior chemotherapy treatment
- Able to read and speak English
- 21 years or older
- Able to provide written informed consent
- Female control participants within 5 years of patient's age
- Control participants able to read and speak English
- Control participants 21 years or older
- Control participants able to provide written informed consent
You will not qualify if you...
- Currently hospitalized or hospitalized within last year for psychiatric illness
- Diagnosis of neurodegenerative disease (e.g., Alzheimer's, Parkinson's)
- Presence of central nervous system disease (e.g., movement disorder, multiple sclerosis)
- History of TIA or stroke within last year or with remaining symptoms
- Scheduled to receive radiation therapy during chemotherapy
- Colorblindness
- Control participants with prior cancer diagnosis or chemotherapy
- MR safety contraindications for optional sub-study MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
S
Sara Alberti
CONTACT
T
Tyler Holler
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here