Actively Recruiting
Effects of Chemotherapy Treatment on Metaboreflex, Mechanoreflex, and Baroreflex Function: PROTECT-08B Study
Led by Centre Paul Strauss · Updated on 2025-12-31
24
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Breast cancer is the most common cancer worldwide, with over 2.2 million new cases diagnosed in 2020. Treatments such as chemotherapy often lead to a reduced exercise capacity, mainly due to cardiovascular and neuromuscular dysfunctions. This decline appears to be primarily caused by increased central fatigue, while peripheral fatigue remains unchanged. This imbalance suggests a hyperactivation of type III-IV afferent nerve fibers, which are involved in the metaboreflex-a mechanism that significantly influences cardiovascular responses during exercise. Two non-invasive methods, post-exercise circulatory occlusion (PECO) and passive leg movement (PLM), will be used to assess this hyperactivity in patients. Additionally, baroreflex function-crucial for regulating blood pressure-will be evaluated using a direct method to determine its sensitivity and reactivity. By comparing patients with healthy controls under submaximal stimuli, this study aims to better understand chemotherapy-induced cardiovascular dysfunctions. Ultimately, the goal is to design personalized exercise programs to restore cardiovascular function and reduce treatment-related side effects.
CONDITIONS
Official Title
Effects of Chemotherapy Treatment on Metaboreflex, Mechanoreflex, and Baroreflex Function: PROTECT-08B Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with stage I to III breast cancer
- Completed (neo)adjuvant chemotherapy treatment less than three weeks ago
- Healthy women with no history of cancer matched by age, weight, and physical activity level
You will not qualify if you...
- History of cancer (other than breast cancer for patient group)
- Any known chronic pathology
- Protected minor or adult
- Psychiatric, musculoskeletal, or neurological problems
- Implantation of a pacemaker
- Pregnant women
- Contraindications to transient blood flow occlusion use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institut de cancérologie Strasbourg Europe
Strasbourg, France, 67100
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
1
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