Actively Recruiting
Effects of Chronic Creatine and Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Oxidative Stress, Inflammation, Muscle Strength, and Body Composition in Individuals With Down Syndrome
Led by Universidad de Burgos · Updated on 2026-01-14
50
Participants Needed
1
Research Sites
36 weeks
Total Duration
On this page
Sponsors
U
Universidad de Burgos
Lead Sponsor
E
European University Miguel de Cervantes
Collaborating Sponsor
AI-Summary
What this Trial Is About
Purpose: This study will test whether 8 weeks of creatine and HMB supplementation can improve muscle strength, body composition, balance, and overall health in people with Down syndrome. Participants will also receive nutrition tips during the study. Who can participate: People with Down syndrome who can perform basic physical tasks. Must provide consent from the participant and legal guardian. What participants will do: Take creatine (3 g/day) and HMB (3 g/day) or placebo for 8 weeks. Complete tests for muscle strength, balance, and cognitive function. Undergo body composition scans and give blood samples for health markers. Timing: All tests and blood samples are taken before and after each 8-week period. Importance: Results will help determine if creatine and HMB can safely improve strength, balance, and overall health in people with Down syndrome.
CONDITIONS
Official Title
Effects of Chronic Creatine and Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Oxidative Stress, Inflammation, Muscle Strength, and Body Composition in Individuals With Down Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Medical confirmation of Down syndrome (trisomy of chromosome 21)
- Ability to perform basic physical tests such as standing up from a chair or walking without assistance
- Informed consent obtained from the participant and their legal representative
You will not qualify if you...
- Diagnosis of chronic kidney disease
- Severe motor limitations preventing required physical tests
- Participation in another nutritional or supplementation study within the last 6 months
- Known allergy to creatine or components of the placebo (inulin)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Universidad de Burgos
Burgos, Burgos, Spain, 09003
Actively Recruiting
Research Team
A
Alba Abia Heras, Nutrition and Dietetics
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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