Study on Effects of Creatine and HMB Supplements on Muscle Strength and Health in Adults with Down Syndrome

What this Trial Is About

Researchers are evaluating whether 8 weeks of daily supplementation with creatine monohydrate and beta-hydroxy-beta-methylbutyrate HMB can improve muscle strength, body composition, balance, cognitive function, and overall health in individuals with Down syndrome. This study is a randomized, placebo-controlled crossover trial that also includes nutritional education to support a balanced diet. The study aims to assess the effects of these supplements on oxidative stress and inflammation markers as well. Participants will take either 3 grams per day of creatine combined with 3 grams per day of HMB or a placebo 6 grams per day of inulin orally for 8 weeks. After the first phase, participants will switch to the other supplementation for another 8 weeks. Nutritional education sessions will be provided throughout the intervention to promote healthy eating and lifestyle habits. Participants will undergo assessments before and after each supplementation period, including body composition scans using dual-energy X-ray absorptiometry DXA and bioimpedance, muscle strength tests like handgrip and lower limb strength, balance tests, cognitive function assessments, and blood tests to measure biomarkers of oxidative stress and inflammation. These evaluations will help researchers understand the physiological and functional effects of the supplements in people with Down syndrome. The total duration of participation spans across both 8-week supplementation periods with all tests conducted at baseline and at the end of each phase.

Effects of Chronic Creatine and Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Oxidative Stress, Inflammation, Muscle Strength, and Body Composition in Individuals With Down Syndrome