Actively Recruiting

Phase Not Applicable
Age: 16Years - 90Years
All Genders
Healthy Volunteers
NCT05453019

Effects of CI on Tinnitus and Its Symptoms

Led by Chinese PLA General Hospital · Updated on 2023-06-06

200

Participants Needed

1

Research Sites

260 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Abnormal activity in the central auditory system is the cause of subjective experience of tinnitus. Electrical stimulation can inhibit the abnormal activity of auditory related neurons in patients with tinnitus. In recent years, the application of electrical stimulation in the treatment of tinnitus is a hot research topic, and has made some progress. However, its treatment is still in the discussion stage, and there is no best scheme suitable for clinical practice. At present, scholars have found that cochlear electrode stimulation can inhibit tinnitus, but its mechanism is not clear. It is difficult to locate the origin of tinnitus, and the location of electrode stimulation and stimulation parameters still need to be further optimized. Because the implanted part of the cochlear implant contains magnets, the patients cannot perform functional MRI. However, the prevalence of tinnitus in this group is very high (67.0\~100.0%, with an average of 80.0%), so it is of great value and significance to study the effect of tinnitus treatment in such patients. In this study, a new clinical electroencephalogram (EEG) technique was used to make up for the lack of MRI imaging in patients with electrode implantation. EEG analyzes the functional connection of different brain regions through EEG test electrodes, uses the traceability function of EEG software to locate the location of tinnitus, analyzes the process of tinnitus inhibition by electrical stimulation, and explains the mechanism of tinnitus inhibition by electrical stimulation from a new perspective.

CONDITIONS

Official Title

Effects of CI on Tinnitus and Its Symptoms

Who Can Participate

Age: 16Years - 90Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients who received cochlear implants at the Auditory Implant Center of the Otorhinolaryngology-Head and Neck Surgery, China PLA General Hospital
  • Age between 16 and 90 years
  • Hearing loss with either tinnitus lasting longer than 0.25 years or no tinnitus before cochlear implant surgery
  • Use of cochlear implants from MED-EL, Cochlear, Advanced Bionics, or Nurotron
  • Voluntary participation in the study
Not Eligible

You will not qualify if you...

  • Non-otogenic tinnitus caused by conditions such as hypertension, heart disease, hyperthyroidism, neurasthenia, hyperlipidemia, etc.
  • Contraindications for cochlear implant surgery according to the 2013 Chinese Medical Association guidelines
  • Intellectual deficiency

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Qian Wang

Beijing, France, China, 100085

Actively Recruiting

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Research Team

Q

QIAN WANG, M.S.

CONTACT

S

Shi m Yang

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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