Fourth Universal Definition of Myocardial Infarction (2018).
Kristian Thygesen, Joseph S Alpert, Allan S Jaffe...
https://pubmed.ncbi.nlm.nih.gov/30571511Actively Recruiting
Phase 4
Age: 40Years - 80Years
All Genders
ID07028593
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Patients Undergoing Video-Assisted Thoracoscopic Surgery
Led by Tongji Hospital · Updated on 2026-01-28
1058
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of Ciprofol, a new intravenous anesthetic drug, on myocardial injury occurring after non-cardiac thoracic surgery. Myocardial injury after noncardiac surgery (MINS) is identified by elevated cardiac troponin levels due to ischemic causes and is a common complication after thoracic surgery, linked to increased risks of mortality and vascular problems. This study aims to see if Ciprofol can reduce the incidence of MINS compared to propofol, focusing on patients undergoing video-assisted thoracoscopic surgery (VATS) for lung cancer treatment. Participants will be randomly assigned to receive either Ciprofol or propofol as sedative agents during general anesthesia for VATS. Both groups will also receive sufentanil and cis-atracurium intravenously. The doses and administration times for study drugs are carefully controlled. The trial is double-blind and multicenter, comparing the circulatory stability and sedative effects of Ciprofol with those of propofol in thoracic surgery patients. During the study, patients will be monitored for myocardial injury within 30 days post-surgery, as well as for new heart rhythm problems, episodes of low blood pressure, and mortality rates. Data on anesthesia induction, maintenance, and perioperative hemodynamics will be collected. The study includes baseline assessments and safety monitoring, with follow-up visits lasting at least three days postoperatively. Researchers will analyze the incidence of myocardial injury and other cardiovascular outcomes to assess the impact of Ciprofol on patient safety and recovery.
CONDITIONS
Brief Title
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery
Who Can Participate
Age: 40Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Scheduled for elective video-assisted thoracoscopic thoracic surgery including lobectomy, segmentectomy, wedge resection of two or more lung tissues, or mediastinal tumor resection under general anesthesia
- Aged 45 to 80 years at the time of randomization
- Expected to stay in the hospital for at least 3 days after surgery
- Signed a written informed consent form to participate in the study
You will not qualify if you...
- Allergy to propofol, Ciprofol, or related drug components such as soybeans, eggs, or milk
- Unstable angina
- Congestive heart failure or hemodynamic instability requiring vasopressor medications
- Severe chronic obstructive pulmonary disease with FEV1 less than 1 liter
- Glomerular filtration rate (eGFR) below 30 mL/min/1.73m²
- Severe liver dysfunction with ALT or AST levels exceeding 1.5 times the upper limit of normal
- Planning to conceive within the next 3 months (male or female)
- Pregnant or breastfeeding females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Day of surgery
Participants undergo video-assisted thoracoscopic surgery with anesthesia induced and maintained using either Ciprofol or Propofol as sedative agents.
1 surgical visit (in-person)
Post-operative Follow-up
Duration - Up to 30 days after surgery
Participants are monitored for myocardial injury and cardiovascular complications following surgery.
Multiple visits during hospital stay and follow-up visits up to 30 days
Trial Site Locations
Total: 1 location
1
Tongji hospital
Wuhan, China
Actively Recruiting
Loading map...
Research Team
A
Ailin Luo, MD&PhD
S
Shiyong Li, MD&PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
In noncardiac thoracic surgery, low-dose colchicine did not reduce AF or myocardial injury after noncardiac surgery at 14 d.
Jose Lopez, Steven Borzak
https://pubmed.ncbi.nlm.nih.gov/38163371Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial.
David Conen, Michael Ke Wang, Ekaterine Popova...
https://pubmed.ncbi.nlm.nih.gov/37640035Changes in mean systemic filling pressure as an estimate of hemodynamic response to anesthesia induction using propofol.
Maayan Zucker, Gregory Kagan, Nimrod Adi...
https://pubmed.ncbi.nlm.nih.gov/35869445The effect of propofol on haemodynamics: cardiac output, venous return, mean systemic filling pressure, and vascular resistances.
F de Wit, A L van Vliet, R B de Wilde...
https://pubmed.ncbi.nlm.nih.gov/27199311Prevention of pain on injection of propofol: systematic review and meta-analysis.
Leena Jalota, Vicki Kalira, Elizabeth George...
https://pubmed.ncbi.nlm.nih.gov/21406529Comparison of the Efficacy of HSK3486 and Propofol for Induction of General Anesthesia in Adults: A Multicenter, Randomized, Double-blind, Controlled, Phase 3 Noninferiority Trial.
Tong J Gan, Todd Bertoch, Ashraf S Habib...
https://pubmed.ncbi.nlm.nih.gov/38150544Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics.
Linlin Qin, Lei Ren, Songlin Wan...
https://pubmed.ncbi.nlm.nih.gov/28430430Efficacy and safety of ciprofol vs. propofol for the induction and maintenance of general anaesthesia: A multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial.
Peng Liang, Meng Dai, Xiao Wang...
https://pubmed.ncbi.nlm.nih.gov/36647565Effects of ciprofol for the induction of general anesthesia in patients scheduled for elective surgery compared to propofol: a phase 3, multicenter, randomized, double-blind, comparative study.
X Wang, X Wang, J Liu...
https://pubmed.ncbi.nlm.nih.gov/35302207