Actively Recruiting
Effects of a Collagen Supplement on Quality of Life, Appetite and Glycaemic Control: a Randomised, Double-blinded, Placebo-controlled, Crossover Trial in Overweight and Obese Adults
Led by King's College London · Updated on 2025-11-14
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
K
King's College London
Lead Sponsor
R
Rousselot BVBA
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether a collagen supplement can improve quality of life, appetite, and blood sugar control in adults aged 18 to 65 who are overweight or obese and have a lower perceived quality of life. The study compares the effects of an 8-day consumption of a collagen peptide supplement versus a placebo in this population, aiming to assess changes in quality of life and glycaemic control. Participants will receive two daily doses of 5 grams of either a hydrolysed bovine collagen peptide supplement or a placebo (maltodextrin) for 8 days. The study uses a randomized, double-blinded, placebo-controlled, crossover design, where each participant takes both the supplement and placebo in different periods. The treatment phases are followed by assessments, and participants cross over between the supplement and placebo to compare effects within the same individual. During the study, participants will complete questionnaires about their quality of life, appetite, mood, energy, and sleep. They will also wear continuous glucose monitors for up to 22 days to track blood sugar levels and responses after meals. Researchers will measure quality of life scores at baseline and after 8 days, along with post-meal appetite, mood, energy, fatigue, sleep quality, glycaemic variability, and dietary habits. The study includes virtual visits and uses mobile apps for data collection over the trial period.
CONDITIONS
Brief Title
Effects of a Collagen Supplement on Quality of Life, Appetite and Glycaemic Control
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy male or female adults aged 18 to 65 years
- Overweight or obese with a BMI between 25 and 40 kg/m2
- Impaired quality of life based on specific questionnaire scores
- Have an email address, internet access, and a compatible smartphone
- Willing and able to comply with study procedures including supplement use and glucose monitoring
- Willing to take a bovine collagen supplement
- Open to participating in an online interview at study end
You will not qualify if you...
- History or presence of uncontrolled or significant pulmonary, cardiac, liver, kidney, endocrine (including diabetes), blood, immune, neurologic, psychiatric, or biliary disorders
- Significant gastrointestinal conditions affecting study product evaluation
- Chronic insomnia or diagnosed sleep disorders
- Female who is pregnant, planning pregnancy, lactating, or unwilling to use contraception
- Known allergy or sensitivity to study product ingredients including bovine products
- History of cancer within past two years except non-melanoma skin cancer
- Recent major trauma or surgery within three months
- Unstable medication or supplement use affecting trial outcomes
- Participation in another biomedical study within 30 days prior
- Employment or financial interest in Darling Ingredients Inc.
- Conditions interfering with informed consent or study compliance
- Vegan, vegetarian, or excludes bovine products for cultural or religious reasons
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 16 days total
Participants take either a collagen peptide supplement or placebo twice daily for 8 days, then switch to the other supplement for another 8 days.
2 treatment periods of 8 days each with assessments during each period
Duration - Up to 1 week after treatment
Participants complete final assessments including online interviews to evaluate quality of life, appetite, mood, sleep, and glycaemic control.
1 online interview and several remote assessments
Trial Site Locations
Total: 1 location
1
Metabolic Research Unit (KCL, Waterloo Campus)
London, London, United Kingdom, SE1 9NH
Actively Recruiting
Research Team
A
Alex Cheok, PhD
A
Ana Rodriguez-Mateos, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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