Study of Ileostomy Content Reinfusion or Retention Enema to Improve Bowel Function in Patients with Low Anterior Resection Syndrome Before Stoma Closure

What this Trial Is About

This research aims to compare the effects of two preoperative prehabilitation treatments on bowel function recovery in patients with low anterior resection syndrome LAR who have an ileostomy before stoma closure. The study evaluates whether reinfusion of ileostomy contents filtrate through the distal ileocolon or retention enema colon improves defecation function compared to traditional perioperative care. Conducted as a single-center randomized controlled trial, it focuses on patients preparing for stoma closure after rectal cancer surgery. Participants in the experimental group collect ileostomy contents, mix them with saline, and filter the mixture for use as an enema. This filtrate is slowly infused into the ileal output end of the ostomy via anterograde enema or transanal retention enema for 15-20 minutes, 2-3 times daily over 4 weeks. Meanwhile, the control group receives routine perioperative management without this intervention. Researchers observe adverse reactions like abdominal pain, distension, and fever during treatment and record daily prehabilitation details and patient weight. Throughout the study, patients are monitored for bowel function recovery, low anterior resection syndrome severity at 1 month and up to 12 months after surgery, quality of life, fecal incontinence, and weight changes. Additional outcomes include inflammatory markers, emergency visits or rehospitalizations related to stoma closure, and postoperative intestinal obstruction incidence. Assessments occur immediately after surgery and during follow-up visits over the course of a year, ensuring comprehensive evaluation of the prehabilitation impact on recovery and complications.

The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma Closure