Actively Recruiting
Effects Of Concentric Cycling Training Protocol During (Neo)Adjuvant Chemotherapy in Breast Cancer Patients: PROTECT-07 Study
Led by Centre Paul Strauss · Updated on 2026-02-02
156
Participants Needed
2
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The association of anthracyclines (ANT) and paclitaxel (Tax) is one of the main treatments used in breast cancer. These treatments are known to induce severe side effects such as a decrease in overall exercise capacity (physical condition) in response to muscle and cardiorespiratory alterations. If exercise may be an effective preventive strategy, it seems important to prescribe the most efficient exercise modality. Among them, concentric cycling (i.e., classic cycling) can significantly induce metabolic stimulus, which is needed for maintaining exercise capacity. The PROTECT-07 study aims to demonstrate the superiority of a training program based on concentric cycling during chemotherapy compared to standard treatment. The duration of the training program is 15 weeks with one session per week.
CONDITIONS
Official Title
Effects Of Concentric Cycling Training Protocol During (Neo)Adjuvant Chemotherapy in Breast Cancer Patients: PROTECT-07 Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Woman 18 years or older
- Diagnosed with stage I to III breast cancer
- Planning (neo)adjuvant treatment combining anthracycline-cyclophosphamide and weekly paclitaxel, with or without trastuzumab
- Affiliated with a social security system
- Able to speak, read, and understand French
You will not qualify if you...
- No prior chemotherapy treatment
- Known cardiac or vascular disease
- Contraindications to physical fitness assessment
- Protected adult status
- Psychiatric, musculoskeletal, or neurological issues
- Pregnant or breastfeeding
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Hôpitaux civils de Colmar
Colmar, France, 68024
Not Yet Recruiting
2
Institut de cancérologie Strasbourg Europe
Strasbourg, France, 67033
Actively Recruiting
Research Team
J
Joris MALLARD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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