Actively Recruiting
Effects of the Contraceptive Implant in Women With Sickle Cell Disease
Led by University of Pennsylvania · Updated on 2025-08-05
22
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to measure the acceptability and impact of the progestin implant on frequency of vaso-occlusive crises, quality of life, and hematologic parameters in women with SCD.
CONDITIONS
Official Title
Effects of the Contraceptive Implant in Women With Sickle Cell Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 18 to 45 years
- Diagnosis of sickle cell disease (SS or SB0)
- At least 1 vaso-occlusive pain episode per month on average in the previous 6 months
- Willing to stop any hormonal contraception at enrollment with a 1-month washout period
- Access to a device capable of receiving text messages
- Able to read and understand English
- Willing to follow study procedures
You will not qualify if you...
- Diagnosis of SC disease
- Use of Depo Provera in the past 6 months
- Changes to sickle cell medications in the past 3 months
- Contraindications to Nexplanon as per clinical standards
- Currently pregnant, pregnant within the last month, or seeking pregnancy
- Currently breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Penn Medicine University City
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
A
Arden McAllister, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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