Actively Recruiting
Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea
Led by Ohio State University · Updated on 2025-07-24
1739
Participants Needed
1
Research Sites
571 weeks
Total Duration
On this page
Sponsors
O
Ohio State University
Lead Sponsor
U
University of Pennsylvania
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.
CONDITIONS
Official Title
Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 30 and 75 years
- For patients with hypertension, no changes in blood pressure medication for at least 3 months
- Willing and able to give informed consent
- Willing and able to complete ambulatory blood pressure monitoring at baseline and after 6 months
- Sleep study performed (Polysomnography or Home Sleep Apnea Study) based on clinical needs
- 4% oxygen desaturation index (ODI4) of 15 or more events per hour on sleep study
- Planned CPAP treatment by treating provider
You will not qualify if you...
- Unable to apply blood pressure cuff due to arm circumference greater than 55 cm, prior breast cancer, or arm structural abnormalities
- Current use of CPAP or dental device for obstructive sleep apnea
- Heart failure category III or IV
- Presence of Cheyne-Stokes Respiration on sleep study
- Predominantly central sleep apnea with apnea-hypopnea index of 15 or more events per hour
- Pregnancy
- History of renal failure or renal transplant
- Self-reported sleep duration less than 5 hours per night on weeknights
- Other sleep disorders
- Use of supplemental oxygen during wakefulness or sleep
- Self-reported illicit drug or marijuana use more than once per week
- Unstable medical conditions such as uncontrolled angina, uncontrolled hypertension, severe chronic obstructive pulmonary disease, active cancer, or unstable psychiatric disease
- Any condition that the lead investigator considers prohibitive for study participation
- Development or adoption of any exclusion criteria during the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Martha Morehouse Medical Pavilion, Suite 2600
Columbus, Ohio, United States, 43221
Actively Recruiting
Research Team
A
ALICIA GONZALEZ ZACARIAS, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here