Actively Recruiting
Effects of Cranberry on Gut and Metabolic Health
Led by Laval University · Updated on 2026-03-10
73
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
L
Laval University
Lead Sponsor
O
Ocean Spray Cranberries, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are exploring how cranberry supplementation affects metabolic health and gut bacteria in adults who are overweight or obese. The study focuses on understanding changes in blood sugar control, insulin sensitivity, blood fats, and the gut microbiome. It is a randomized, double-blind, placebo-controlled crossover trial designed to clarify cranberry's impact on intestinal health and overall metabolism. Participants will take part in two 12-week intervention periods: one involving daily consumption of a 240 ml cranberry beverage and the other a placebo beverage, with a 4-week break between these phases. Before the interventions, there will be a 2-week phase to stabilize lifestyle habits. Some female participants will also undergo liver fat imaging using MRI to assess changes in fat accumulation. During the study, participants will have comprehensive assessments including blood tests for glucose, insulin, and lipid levels, body composition measurements, gut microbiota analysis, and evaluations of inflammation and appetite. These evaluations will occur before and after each treatment period. The total duration includes the lifestyle stabilization, two treatment periods, and a washout phase, with ongoing monitoring of health markers related to obesity and metabolism.
CONDITIONS
Brief Title
Effects of Cranberry on Gut and Metabolic Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index between 25 and 40 kg/m2
- Age between 25 and 70 years
- At least one of the following: fasting plasma insulin greater than 60 pmol/L, fasting blood sugar between 5.5 and 6.9 mmol/L, glycated hemoglobin (HbA1c) between 5.7% and 6.4%, or fasting triglycerides above 1.35 mmol/L
You will not qualify if you...
- Aversion to cranberry products
- Regularly drinking more than 2 glasses of alcohol per day
- Significant body weight change (±5%) in the past 3 months due to surgery or other conditions
- Use of medications affecting study outcomes such as antidiabetic, cholesterol or lipid-lowering drugs, high-dose glucocorticosteroids, or anti-obesity medications
- Regular use of probiotics, prebiotics, or fruit/berry polyphenol supplements in the past 3 months
- Eating disorders
- Major surgery within 3 months prior to the study or planned surgery
- Intestinal malabsorption, liver cirrhosis, or chronic kidney disease
- Pregnancy, planning pregnancy, or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks per treatment period
Participants consume 240 ml of cranberry beverage or placebo daily for 12 weeks during each treatment period.
Pre and post each treatment period visits (2 visits per treatment period)
Trial Site Locations
Total: 1 location
1
INAF, Université Laval
Québec, Quebec, Canada, G1V0A6
Actively Recruiting
Research Team
J
Julie Marois, M.Sc.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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