Actively Recruiting
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
Led by University of Northern Iowa · Updated on 2026-03-16
20
Participants Needed
1
Research Sites
59 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supplementation alter urinary markers of inflammation (cytokines) during exercise in the heat when compared to placebo? 2. Does one-week of creatine supplementation alter markers of AKI during exercise in the heat when compared to placebo? 3. Does one-week of creatine supplementation attenuate reductions in cognitive measures as a response of fatigue from exertional heat stress. Researchers will compare creatine monohydrate to a placebo (maltodextrin) to see if it alters inflammation, risk of acute kidney injury, and cognition after exercise in the heat. Participants will : * Complete a baseline aerobic exercise test to measure VO2max * Ingest 20 grams per day of creatine monohydrate or placebo (maltodextrin) for seven consecutive days * Cycle for 90 minutes in a heated chamber (38 C, \~40% relative humidity), alternating low- and high-intensity exercise * Self-collect urine before, after, and one-hour after exercise * Self-insert a rectal thermistor to measure core temperature * Complete cognitive tasks using the NIH toolbox before and after exercise to assess cognition * Complete the other condition (placebo or creatine) at least 21 days later
CONDITIONS
Official Title
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years old
- Active physical activity level: planned exercise at least 3 times per week for at least 30 minutes per session over the past 3 months
- Aerobic fitness classified as at least 'good' by ACSM criteria measured by maximal oxygen uptake test
- Free from known cardiovascular, metabolic, kidney, or neurological conditions
- No physical limitations to cycling for about 90 minutes
- No creatine supplementation use in the past 4 weeks
- No illness, vomiting, or diarrhea in the previous 3 days
You will not qualify if you...
- Known allergy to creatine or maltodextrin
- History of severe heat-related events such as heat exhaustion, heat stroke, or dehydration requiring medical care
- Use of medications or supplements that affect thermoregulation, heart rate, kidney injury, or blood pressure responses during exercise (e.g., NSAIDs)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Wellness and Recreation Center
Cedar Falls, Iowa, United States, 50614
Actively Recruiting
Research Team
A
Assistant Professor, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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