Actively Recruiting
Effects of Cycle Therapy vs Sequential Therapy With Romosozumab and Denosumab in Postmenopausal Osteoporosis Patients
Led by National Taiwan University Hospital · Updated on 2025-12-19
70
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective, randomized, controlled clinical trial comparing the efficacy of a 24-month cyclic therapy regimen (6 months of Romosozumab followed by 6 months of Denosumab, repeated for two years) versus a traditional sequential treatment regimen (12 months of Romosozumab followed by 12 months of Denosumab). The goal is to determine which approach yields better therapeutic outcomes and to optimize drug strategies for osteoporosis patients.
CONDITIONS
Official Title
Effects of Cycle Therapy vs Sequential Therapy With Romosozumab and Denosumab in Postmenopausal Osteoporosis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postmenopausal women aged 50 to 90 years
- Bone mineral density T-score 3.0 at any lumbar vertebra
- Physically and mentally able to understand and follow study procedures
- Signed informed consent
You will not qualify if you...
- Previous osteoporosis treatments in the last two years including Romosozumab, Teriparatide, Denosumab, and bisphosphonates
- Allergy to Romosozumab or Denosumab
- Secondary osteoporosis
- Autoimmune diseases
- Chronic steroid use (e.g., COPD patients)
- High or low calcium levels
- Other metabolic bone diseases
- Primary or metastatic bone tumors
- Active cancer except treated in situ carcinoma or non-melanoma skin cancer in remission for five years
- Planned dental procedures within the next year
- History of stent placement, heart attack, stroke, or coronary artery disease
- Kidney disease with creatinine > 1.5 mg/dL or on dialysis
- Smoking more than one pack per day (except those who quit over ten years ago)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
F
Fon-Yih Tsuang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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