Actively Recruiting
Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm
Led by Montefiore Medical Center · Updated on 2026-04-23
40
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
Sponsors
M
Montefiore Medical Center
Lead Sponsor
R
Revance Therapeutics, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test the effects of DaxibotulinumtoxinA-Lanm (Daxxify) in patients with benign essential blepharospasms (BEB) and hemifacial spasms (HFS). The main questions to answer: 1. Is there clinically significant difference (measured by Jankovic Rating Scale (JRS) score from base to peak efficacy) for patients with BEB and HFS treated with Daxxify? 2. What percentage of patients achieve a clinical response? Participants historically treated with Botox for either BEB or HFS will be crossed over to Daxxify treatment in order to serve as their own control and examine the efficacy of Daxxify.
CONDITIONS
Official Title
Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with benign essential blepharospasm (BEB) or hemifacial spasm (HFS) by an ophthalmologist
- Not taking any neurologic or neuromuscular systemic medications
- No history of surgery for BEB or HFS
- Have a minimum score of 4 out of 8 on the modified Jankovic Rating Scale for Severity/Frequency
- At least 18 years old
You will not qualify if you...
- Younger than 18 years old
- Pregnant
- Not willing to participate
- Have contraindications to botulinum toxin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Montefiore Medical Center
The Bronx, New York, United States, 10466
Actively Recruiting
Research Team
I
Isaac M Weber, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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