Effects of Systemic Administration of Dexmedetomidine on Intraocular Pressure During Scheduled Spine Surgeries in a Prone Position Prospective, Randomized, Double-blinded Study

What this Trial Is About

Researchers are studying the effects of giving dexmedetomidine during spine surgeries performed with patients lying face down under general anesthesia. This trial aims to see how this drug affects the pressure inside the eyes, called intraocular pressure (IOP), which can be important for patient safety during surgery. The study is a prospective, randomized, placebo-controlled, double-blinded clinical trial involving adult patients with ASA physical status I, II, or III. Participants will be randomly assigned to one of two groups. One group will receive dexmedetomidine as a bolus dose of 1.0 microgram per kilogram 10 minutes before anesthesia induction, followed by a continuous infusion of 0.4 to 0.8 microgram per kilogram per hour until the surgery ends. The other group will receive an identical volume of normal saline as placebo in the same schedule. All patients will receive the same type of anesthesia using propofol and postoperative pain management with paracetamol and wound infiltration with ropivacaine. During the surgery, various vital signs and parameters will be monitored, including heart rate, blood pressure, oxygen levels, cardiac output, and urine output. Eye pressure will be measured in both eyes at multiple time points before, during, and after surgery using a specialized tonometer by an ophthalmologist who does not know the treatment group. The main outcome measured is the intraocular pressure up to 15 minutes after surgery ends. The study will also calculate ocular perfusion pressure as part of the monitoring. Participation duration depends on the surgery and follow-up measurements shortly after.

Effects of Dexmedetomidine on Intraocular Pressure During Scheduled Spine Surgeries