Actively Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
Led by Children's Oncology Group · Updated on 2025-05-23
420
Participants Needed
79
Research Sites
617 weeks
Total Duration
On this page
Sponsors
C
Children's Oncology Group
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.
CONDITIONS
Official Title
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Previously enrolled leukemia and lymphoma survivors randomized to receive or not receive dexrazoxane hydrochloride on specific studies
- Leukemia and lymphoma survivors alive and in continuous first complete remission without progressive disease or off-protocol therapy
- No diagnosis of subsequent malignancy requiring additional cardiotoxic therapies
- Consent signed by patients or parents/legal guardians
- Osteosarcoma survivors previously enrolled on specific study and able to provide consent
- Comparison osteosarcoma patients with biopsy-proven moderate or high grade disease diagnosed 1999-2002 without metastasis
- No poor or low cardiac function at initial osteosarcoma diagnosis
- Comparison subjects must have records documenting lifetime receipt of doxorubicin within specified doses
- No exposure to other anthracyclines or dexrazoxane for comparison subjects
- Individuals diagnosed with cancer before age 21, treated with chemotherapy and/or radiotherapy, in remission at least 1 year
- Screening echocardiograms available in suitable digital format
- No known congenital heart disease or genetic syndrome affecting cardiovascular health
- Echocardiogram measurements showing reduced left ventricular function on at least two occasions
- Chronic medical therapy for cardiomyopathy if low function observed on one occasion
- All FDA and NCI requirements for human studies met
You will not qualify if you...
- Enrollment closed for study strata I, II, and III as of March 31, 2021, except for medical record submission in stratum IV
- Diagnosis of subsequent malignancy requiring additional cardiotoxic therapies
- No available or unsuitable echocardiogram images (e.g., VHS tapes or reports without images)
- Known congenital heart disease (excluding patent foramen ovale) or genetic syndromes affecting heart health
- Echocardiogram measurements not meeting criteria for reduced left ventricular function
- Presence of sepsis or uncontrolled infection at time of low heart function measurement
- Failure to provide informed consent by patient or legal guardian
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 79 locations
1
Children's Hospital of Alabama
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
3
Banner University Medical Center - Tucson
Tucson, Arizona, United States, 85719
Actively Recruiting
4
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202-3591
Actively Recruiting
5
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
6
Valley Children's Hospital
Madera, California, United States, 93636
Active, Not Recruiting
7
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
Actively Recruiting
8
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
9
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
Actively Recruiting
10
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
11
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States, 33908
Actively Recruiting
12
University of Florida Health Science Center - Gainesville
Gainesville, Florida, United States, 32610
Suspended
13
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, United States, 33021
Active, Not Recruiting
14
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
15
Nemours Children's Hospital
Orlando, Florida, United States, 32827
Actively Recruiting
16
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, United States, 33701
Active, Not Recruiting
17
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, United States, 33607
Actively Recruiting
18
Saint Mary's Hospital
West Palm Beach, Florida, United States, 33407
Actively Recruiting
19
Children's Healthcare of Atlanta - Egleston
Atlanta, Georgia, United States, 30322
Actively Recruiting
20
University of Hawaii Cancer Center
Honolulu, Hawaii, United States, 96813
Active, Not Recruiting
21
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States, 96826
Actively Recruiting
22
Lurie Children's Hospital-Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
23
University of Illinois
Chicago, Illinois, United States, 60612
Active, Not Recruiting
24
Advocate Children's Hospital-Oak Lawn
Oak Lawn, Illinois, United States, 60453
Actively Recruiting
25
Saint Jude Midwest Affiliate
Peoria, Illinois, United States, 61637
Actively Recruiting
26
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
Actively Recruiting
27
Maine Children's Cancer Program
Scarborough, Maine, United States, 04074
Actively Recruiting
28
Sinai Hospital of Baltimore
Baltimore, Maryland, United States, 21215
Actively Recruiting
29
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, United States, 21287
Actively Recruiting
30
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
31
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Active, Not Recruiting
32
Ascension Saint John Hospital
Detroit, Michigan, United States, 48236
Actively Recruiting
33
Hurley Medical Center
Flint, Michigan, United States, 48503
Active, Not Recruiting
34
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
35
Columbia Regional
Columbia, Missouri, United States, 65201
Active, Not Recruiting
36
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
37
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States, 89102
Actively Recruiting
38
Sunrise Hospital and Medical Center
Las Vegas, Nevada, United States, 89109
Actively Recruiting
39
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, United States, 89135
Actively Recruiting
40
Summerlin Hospital Medical Center
Las Vegas, Nevada, United States, 89144
Actively Recruiting
41
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Active, Not Recruiting
42
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
43
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States, 87102
Actively Recruiting
44
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Suspended
45
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, United States, 11040
Actively Recruiting
46
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
47
Stony Brook University Medical Center
Stony Brook, New York, United States, 11794
Actively Recruiting
48
State University of New York Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
49
Mission Hospital
Asheville, North Carolina, United States, 28801
Actively Recruiting
50
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
51
Children's Hospital Medical Center of Akron
Akron, Ohio, United States, 44308
Actively Recruiting
52
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
53
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
54
Legacy Emanuel Children's Hospital
Portland, Oregon, United States, 97227
Actively Recruiting
55
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
56
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, United States, 19134
Actively Recruiting
57
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Actively Recruiting
58
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
59
BI-LO Charities Children's Cancer Center
Greenville, South Carolina, United States, 29605
Actively Recruiting
60
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
Active, Not Recruiting
61
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Actively Recruiting
62
Cook Children's Medical Center
Fort Worth, Texas, United States, 76104
Suspended
63
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
64
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
65
University of Vermont and State Agricultural College
Burlington, Vermont, United States, 05405
Actively Recruiting
66
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
67
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
68
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, United States, 99204
Actively Recruiting
69
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
70
Princess Margaret Hospital for Children
Perth, Western Australia, Australia, 6008
Active, Not Recruiting
71
Perth Children's Hospital
Perth, Western Australia, Australia, 6009
Actively Recruiting
72
Alberta Children's Hospital
Calgary, Alberta, Canada, T3B 6A8
Actively Recruiting
73
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8N 3Z5
Suspended
74
Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada, K1H 8L1
Active, Not Recruiting
75
Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Suspended
76
The Montreal Children's Hospital of the MUHC
Montreal, Quebec, Canada, H3H 1P3
Actively Recruiting
77
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada, H3T 1C5
Actively Recruiting
78
Centre Hospitalier Universitaire de Quebec
Québec, Canada, G1V 4G2
Actively Recruiting
79
San Jorge Children's Hospital
San Juan, Puerto Rico, 00912
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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