Actively Recruiting
Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis
Led by University of Karachi · Updated on 2026-02-11
150
Participants Needed
2
Research Sites
54 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A randomized controlled trial will be conducted at the Department of Physiotherapy, Dr. Ziauddin Hospital and Al-Rayaz Hospital, Karachi, Pakistan. A total of 150 patients diagnosed with knee osteoarthritis, aged between 40-60 years, will be recruited through a non-probability purposive sampling technique. Written informed consent will be obtained from all eligible participants prior to enrollment. The participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group, with 75 participants in each group. Group A (experimental group) will receive diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises, while Group B (control group) will receive conventional strength training exercises. Heat therapy will be administered to both groups. All participants will be assessed using a standardized assessment form. Outcome measures will include pain intensity, knee range of motion, functional disability, hamstring flexibility, dynamic balance, and fatigue level. A single blinded assessor will assess all participants at baseline and at post intervention. Treatment sessions will be given thrice a week on alternate days for 6 weeks.
CONDITIONS
Official Title
Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Both males and females aged between 40 and 60 years
- Diagnosed with unilateral or bilateral Knee Osteoarthritis
- Classified as Grade II or Grade III on Kellgren and Lawrence scale
- Pain intensity greater than 3.4 cm on Visual Analogue Scale
- Knee osteoarthritis duration longer than 3 months (chronic)
You will not qualify if you...
- Presence of any neurological disorder
- History of lower limb arthroplasty or knee surgery
- Septic knee arthritis
- Inflammatory rheumatic diseases such as rheumatoid arthritis or gout
- Cancer or other malignancies like bone tumors
- Knee deformities including contracture, genu valgum, or genu varum
- History of ligament injury or meniscal tear
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Al-Rayaz Hospital
Karachi, Sindh, Pakistan, 74600
Actively Recruiting
2
Dr. Ziauddin Hospital
Karachi, Sindh, Pakistan, 74600
Actively Recruiting
Research Team
R
Rabia Hassan, MSAPT
CONTACT
B
Basit Ansari, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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