Actively Recruiting
Led by University of Karachi · Updated on 2026-02-11
150
Participants Needed
2
Research Sites
4 weeks
Total Duration
Researchers are studying knee osteoarthritis in adults aged 40 to 60 years to compare the effects of diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises and conventional strength training exercises. The trial aims to evaluate how these exercise programs affect pain intensity, knee range of motion, functional disability, hamstring flexibility, dynamic balance, and fatigue levels in patients with this condition. The study will be conducted at two hospitals in Karachi, Pakistan, with 150 participants randomly assigned to two groups. One group will receive diagonal PNF pattern exercises focusing on two lower limb patterns performed against resistance to improve strength and flexibility, combined with heat therapy. The other group will receive conventional strength training exercises targeting quadriceps and hip abductor muscles, also combined with heat therapy. Both groups will undergo treatment sessions three times per week on alternate days for six weeks. Participants will be assessed by a single blinded assessor at the start and after the 18th treatment session using standardized tools including the Visual Analogue Scale for pain, Universal Goniometer for knee range of motion, Knee Injury and Osteoarthritis Outcome Score for functional disability, Active Knee Extension test for hamstring flexibility, Four Step Square Test for dynamic balance, and a Multidimensional Fatigue Inventory questionnaire. Data will be analyzed to compare changes in these outcomes, with safety and progress monitored throughout the trial.
CONDITIONS
Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 6 weeks
Participants receive diagonal proprioceptive neuromuscular facilitation pattern exercises or conventional strength training exercises, both combined with heat therapy.
18 intervention sessions
Total: 2 locations
1
Al-Rayaz Hospital
Karachi, Sindh, Pakistan, 74600
Actively Recruiting
2
Dr. Ziauddin Hospital
Karachi, Sindh, Pakistan, 74600
Actively Recruiting
R
Rabia Hassan, MSAPT
B
Basit Ansari, PhD
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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