Actively Recruiting
Effects of Dietary Nitrate in Women With Secondary Amenorrhea
Led by Indiana University · Updated on 2025-09-24
12
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Excessive exercise, disordered attitudes toward eating, physical and psychological stress, and/or hormonal imbalances may result in cessation of menstruation (secondary amenorrhea). The accompanying lack of estrogen may impair muscle power and oxygen recovery after exercise by reducing nitric oxide levels. The purpose of this study is to determine whether ingestion of beetroot juice containing nitrate, an alternative source of nitric oxide, can help reverse these changes.
CONDITIONS
Official Title
Effects of Dietary Nitrate in Women With Secondary Amenorrhea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women age 18-44 years old
- Missed more than 3 consecutive periods in the last 12 months if previously regularly menstruating (average cycle 21-35 days)
- Missed more than 6 consecutive periods in the last 12 months if previously irregularly menstruating (average cycle less than 21 or greater than 35 days)
You will not qualify if you...
- Unable to provide informed consent
- Diagnosed with primary amenorrhea or oligomenorrhea
- Diagnosed with chronic illnesses including thyroid disease, hyperprolactinemia, Cushing syndrome, or polycystic ovarian syndrome
- History or current diagnosis of an eating disorder
- Currently dieting
- Weight instability in the past 3 months
- Previous revascularization procedures involving femoral or popliteal arteries
- Using hormonal contraceptives currently or in the past year
- Pregnancy
- Epilepsy
- Current antibiotic use
- Current nicotine use
- Stage II hypertension (resting blood pressure over 140/90)
- Taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or hormone replacement therapy
- Any positive answer to Physical Activity Readiness Questionnaire questions indicating not ready for exercise without medical exam
- Any known reason advised by a doctor to avoid physical activity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Indiana University Indianapolis
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
A
Andrew R Coggan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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