Actively Recruiting
The Effects of Dietary Supplementation on Serum Protein Glycosylation
Led by University of California, Davis · Updated on 2025-12-02
44
Participants Needed
1
Research Sites
218 weeks
Total Duration
On this page
Sponsors
U
University of California, Davis
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Two randomized double-blind placebo-controlled clinical studies to assess the effects of dietary glycan monomer supplementation on the immune system, especially antibody glycosylation in healthy adults. Immune profiling and glycoproteomics will be performed on serum isolated at these same time points.
CONDITIONS
Official Title
The Effects of Dietary Supplementation on Serum Protein Glycosylation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult men and women aged 18 to 45 years
- In general good health
- Body Mass Index (BMI) between 18.5 and 25
You will not qualify if you...
- Age younger than 18 or older than 45 years
- Women who are pregnant, nursing, or had a pregnancy within the past year
- Women who are peri-menopausal or post-menopausal
- Women with irregular menstrual cycles
- Women using hormonal contraception or hormonal intrauterine devices
- History of autoimmune conditions or cancer (except non-melanoma skin cancer)
- Cardiovascular, pulmonary, reproductive, endocrine, metabolic, neurologic, gastrointestinal, hematologic, or infectious diseases
- Diagnosed with galactosemia or congenital disorders of glycosylation
- Diagnosed with phenylketonuria
- Use of prescription medications in the last 3 months
- Use of over-the-counter medications
- Use of supplements including herbal, protein, or vitamin supplements in the last 3 months, except multivitamins
- BMI less than 18.5 or greater than 25
- History of severe food or drug allergic reactions
- Allergic reactions to shellfish, N-acetylglucosamine, galactose, Spirulina/chlorella/algae supplements, or arabinose-containing products
- First-degree relative with autoimmune conditions
- Current use of tobacco, alcohol, or drugs
- Certain dietary or exercise habits such as active dieting, vegan diet, high tea/coffee/juice intake, intensive exercise, soda/energy drink consumption, frequent fast food, high alcohol intake
- Following carbohydrate-restricted, Paleo, or calorie-restricted diets
- Unable to consent
- Prisoners
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California, Davis Medical Center
Sacramento, California, United States, 95816
Actively Recruiting
Research Team
E
Emanual Maverakis, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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