Study Comparing Two Types of Continuous Renal Replacement Therapy on Ionized Calcium Levels in Patients Using Citrate Anticoagulation with Calcium-Containing Replacement Fluids

What this Trial Is About

Researchers are investigating how different methods of continuous renal replacement therapy CRRT affect ionized calcium levels when using regional citrate anticoagulation with calcium-containing replacement fluids. The study aims to compare two CRRT modescontinuous veno-venous hemofiltration CVVH and continuous veno-venous hemodialysis CVVHDto understand their impact on calcium concentrations during treatment. Participants will be randomly assigned to receive either CVVH or CVVHD first, then switch to the other mode during their next treatment session. Measurements of pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent calcium will be taken two hours after starting CRRT. Electrolytes, arterial blood gases, and citrate doses will be monitored every six hours until CRRT ends. During the study, patients will undergo regular blood tests and monitoring to assess calcium levels and metabolic complications. The main outcomes focus on differences in ionized calcium at various points during treatment and the occurrence of new metabolic issues within 48 hours. Participants will be observed throughout their CRRT treatment period, with data collected to evaluate the therapies effects.

Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions