Actively Recruiting
Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
Led by Fujian Provincial Hospital · Updated on 2025-08-06
30
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It is unclear whether different modes of continuous renal replacement therapy (CRRT) impact post-filter ionized calcium concentrations during regional citrate anticoagulation (RCA) when using calcium-containing replacement fluid. This prospective, single-center, observational cohort study will screen all patients receiving CRRT for eligibility. General clinical information will be collected before commencing CRRT treatment. Patients will be randomly assigned to either the veno-venous hemofiltration (CVVH) or continuous veno-venous hemodialysis (CVVHD) group and switch to the alternative mode in the subsequent treatment session. Pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent total and ionized calcium will be measured 2 hours after the initiation of CRRT. Electrolyte levels, arterial blood gases, hourly citrate dose, and total citrate dose will be recorded every 6 hours until the end of CRRT. The primary outcome is the difference in ionized calcium concentrations at each site over time between the two modes.
CONDITIONS
Official Title
Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Receiving citrate anticoagulation
- Informed consent obtained from patient or next of kin
You will not qualify if you...
- Pregnant or lactating women
- Allergy to citrate anticoagulants
- Severe liver dysfunction (total bilirubin more than twice normal range)
- Low blood oxygen levels (PaO2 less than 60 mmHg)
- Poor tissue perfusion (blood pressure below 90/60 mmHg despite high doses of vasoactive agents)
- High lactate levels (lactate above 4 mmol/L)
- High sodium levels (hypernatremia)
- Expected hospital stay less than 48 hours
- Participation in other studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fujian Provincial Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
Research Team
H
Han Chen, Ph.D., M.D.
CONTACT
W
Wan-Li Yan, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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