Actively Recruiting
Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium Using Citrate Anticoagulants with Calcium-containing Replacement Solutions
Led by Fujian Provincial Hospital · Updated on 2025-08-06
30
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how different methods of continuous renal replacement therapy (CRRT) affect ionized calcium levels when using regional citrate anticoagulation with calcium-containing replacement fluids. The study aims to compare two CRRT modes—continuous veno-venous hemofiltration (CVVH) and continuous veno-venous hemodialysis (CVVHD)—to understand their impact on calcium concentrations during treatment. Participants will be randomly assigned to receive either CVVH or CVVHD first, then switch to the other mode during their next treatment session. Measurements of pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent calcium will be taken two hours after starting CRRT. Electrolytes, arterial blood gases, and citrate doses will be monitored every six hours until CRRT ends. During the study, patients will undergo regular blood tests and monitoring to assess calcium levels and metabolic complications. The main outcomes focus on differences in ionized calcium at various points during treatment and the occurrence of new metabolic issues within 48 hours. Participants will be observed throughout their CRRT treatment period, with data collected to evaluate the therapies' effects.
CONDITIONS
Brief Title
Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Receiving citrate anticoagulation
- Able to provide informed consent or have consent from next of kin
You will not qualify if you...
- Pregnant or lactating women
- Allergy to citrate anticoagulants
- Severe liver dysfunction with bilirubin over twice normal
- Low blood oxygen levels (PaO2 < 60 mmHg)
- Low blood pressure despite high-dose vasoactive drugs
- High blood lactate (> 4 mmol/L)
- High blood sodium levels
- Expected hospital stay less than 48 hours
- Participation in other clinical studies recently
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 48 hours after the initiation of therapy
Participants are observed while receiving continuous renal replacement therapy with citrate anticoagulants and calcium-containing replacement solutions.
1 to 2 visits during the first 48 hours
Trial Site Locations
Total: 1 location
1
Fujian Provincial Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
Research Team
H
Han Chen, Ph.D., M.D.
W
Wan-Li Yan, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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