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Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia
Led by China Medical University, China · Updated on 2026-01-26
1176
Participants Needed
16
Research Sites
104 weeks
Total Duration
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AI-Summary
What this Trial Is About
This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery.
CONDITIONS
Official Title
Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age not less than 65 years
- American Society of Anesthesiologists grades I-III
- No history of drug allergies or abnormal anesthesia
- Expected duration of mechanical ventilation more than 2 hours
- Scheduled for laparoscopic gastrointestinal surgery
- Preoperative oxygen saturation not less than 94%
- Planned extubation in the operating room
You will not qualify if you...
- History of acute lung injury or acute respiratory distress syndrome within 3 months
- Cardiac function Class IV (New York Heart Association classification)
- Chronic renal failure with filtration rate less than 30 ml/min/1.73 m2 or severe liver disease
- Blurred consciousness or cognitive dysfunction
- Severe coagulation dysfunction
- No preoperative oxygen inhalation with blood oxygen level below 94% or severe pulmonary dysfunction
- Patients admitted to ICU with endotracheal tubes after surgery
- Body mass index greater than 30 kg/m2
- Inability to complete the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
the First Hospital of China Medical University
Shenyang, Liaoning, China, 110001
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2
Beijing Friendship Hospital, Capital Medical University
Beijing, China
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3
Sichuan Provincial People's Hospital
Chendu, China
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4
Chifeng Municipal Hospital
Chifeng, China
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5
Dalian Third People's Hospital
Dalian, China
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6
First Affiliated Hospital, Dalian Medical University
Dalian, China
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7
First Affiliated Hospital of Harbin Medical University
Harbin, China
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8
Harbin Medical University Cancer Hospital
Harbin, China
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9
First Medical University and Shandong Provincial Qianfoshan Hospital
Jinan, China
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10
First Affiliated Hospital of Kunming Medical University
Kunming, China
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11
Affiliated Hospital of Qingdao University
Qingdao, China
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12
Liaoning Cancer Hospital and Institute
Shenyang, China
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13
Shenzhen People's Hospita
Shenzhen, China
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14
First Hospital of Hebei Medical University
Shijia Zhuang, China
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15
Second Hospital of Hebei Medical University
Shijia Zhuang, China
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16
YANBIAN University Hospital（Yanbian Hospital）
Yanbian, China
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Research Team
T
Tianhao Zhang, M.D.
CONTACT
Y
Yang An, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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