Comparing 40% and 80% Inhaled Oxygen Levels on Lung Function in Older Adults Undergoing Laparoscopic Gastrointestinal Surgery Under General Anesthesia

What this Trial Is About

Researchers are evaluating the effects of different inhaled oxygen concentrations on lung function in older patients undergoing laparoscopic gastrointestinal surgery under general anesthesia. This multicenter, prospective, randomized controlled study compares low oxygen concentration 40% and high oxygen concentration 80% during surgery in patients aged 65 and older. The study aims to understand how these oxygen levels impact lung function and postoperative recovery. Participants will be randomly assigned to one of two groups one receiving 80% oxygen and the other receiving 40% oxygen after anesthesia induction. Both groups will follow a lung-protective ventilation strategy with specific respiratory parameters. Manual lung recruitment maneuvers will be performed after intubation and before extubation. Blood samples for gas analysis will be collected within 48 hours after surgery to assess outcomes. During the study, participants will be closely monitored with respiratory assessments and blood gas analyses, focusing on the oxygenation index 48 hours post-surgery. Secondary measures include pulmonary complications within 7 days and mortality within 30 days. The study involves multiple centers and plans to enroll 1098 subjects. The total duration of participation includes the surgical procedure and follow-up assessments up to 30 days after surgery.

Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia