Comparing Inspiratory Muscle Training Methods to Improve Lung and Muscle Function in Adults Undergoing Hematopoietic Stem Cell Transplantation

What this Trial Is About

Researchers are evaluating how different inspiratory muscle training IMT methods affect patients undergoing hematopoietic stem cell transplantation HSCT. This study focuses on improving respiratory muscle strength and endurance, reducing breathlessness, and enhancing exercise capacity and quality of life. It also examines diaphragm function, muscle strength, fatigue, oxidative stress, and inflammatory and muscle biomarkers in these patients. The trial is a prospective, randomized controlled, and single-blinded study designed to compare the effects of various IMT protocols during the transplantation process. Participants will be divided into three groups one receiving standard inspiratory muscle training using the PowerBreathe Classic device at 40% of their maximum inspiratory pressure MIP, a functional inspiratory muscle training group combining IMT with functional exercises three times a week, and a control group performing sham IMT at 10% MIP. All groups will train twice daily, five days a week, during the transplantation period, with functional group exercises supervised by a physiotherapist. Vital signs and other safety parameters will be monitored throughout the training sessions. Patients will be assessed three times before exercise therapy, before and after starting the preparatory regime, and after exercise therapy post-transplant. Evaluations include breathlessness perception, cardiopulmonary function, respiratory muscle strength and endurance, diaphragm function, inflammatory and oxidative stress markers, muscle biomarkers, pulmonary function tests, peripheral muscle strength, fatigue, depression, and quality of life. The study will continue for about one year, with close monitoring of physical and biochemical outcomes to determine the impact of different inspiratory muscle training protocols on transplant recipients.

Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients