Actively Recruiting
Effects of Different Ventilation Methods on Inflammation and Lung Function in Patients Undergoing Pulmonary Lobe Resection
Led by Mao Enting · Updated on 2024-07-23
102
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of different ventilation methods on patients undergoing pulmonary lobe removal, focusing on inflammatory factors in the blood and lung function. This research includes patients with lung injury or inflammation who are scheduled for lobe resection surgery. The study aims to evaluate how these ventilation modes impact recovery after surgery. Participants are randomly assigned to one of three groups during surgery. One group receives volume control ventilation on the ventilated lung combined with continuous positive airway pressure on the non-ventilated lung. Another group also receives volume control ventilation and continuous positive pressure ventilation on the non-ventilated side. The third group receives pressure-regulated volume control ventilation on the ventilated side combined with continuous positive pressure ventilation on the non-ventilated side. These ventilation methods are applied during the operation. During the study, participants are monitored for lung infection risk within 15 days after surgery using a clinical pulmonary infection score. Researchers will collect data on inflammatory markers and respiratory function. The study involves comprehensive assessments before and after surgery to evaluate the effects of the ventilation strategies on lung recovery and inflammation.
CONDITIONS
Official Title
The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed clearly with indications for pulmonary lobe resection based on imaging and laboratory exams
- Age between 18 and 75 years
- No gender restriction
- ASA physical status classification I to III
- Expected single lung ventilation time between 1 and 3 hours
You will not qualify if you...
- Emergency surgery
- Contraindications to systemic anesthesia
- History of acute or chronic upper respiratory infections in the past month
- History of bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation, tuberculosis, aspergillosis, acute respiratory distress syndrome, or respiratory failure
- Dysfunction of important organs such as heart, liver, or kidney
- History of chest surgery or trauma
- Abnormal preoperative lung function test with FEV1 less than 60%
- Refusal to participate in the clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou, China, 563000
Actively Recruiting
Research Team
M
Mao Enting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
OTHER
Number of Arms
3
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