Actively Recruiting
Effects of Dietary Nitrate Supplementation Using Beetroot Juice on Exercise Endurance in Patients With Fibrotic Interstitial Lung Disease
Led by University of British Columbia · Updated on 2025-01-15
15
Participants Needed
2
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of dietary nitrate supplementation on exercise performance in people with fibrotic interstitial lung disease (ILD). This group of lung disorders causes scarring and inflammation leading to breathing difficulties and reduced exercise capacity. The study aims to see if drinking beetroot juice rich in nitrate can improve endurance during exercise compared to nitrate-free beetroot juice in patients with ILD. Participants will consume two beverages daily for seven days. One group will drink concentrated beetroot juice containing 400mg of nitrate per serving, while the other group will receive beetroot juice with only trace amounts of nitrate as a placebo. This supplementation is designed to test whether nitrate-rich juice can enhance exercise tolerance during a structured pulmonary rehabilitation program. During the study, participants will be assessed for how long they can sustain cycling exercise at a constant work rate. Researchers will monitor exercise endurance time, lung function, and oxygen levels. The primary outcome is the difference in exercise endurance after one week of dietary nitrate versus placebo. The study includes clinical evaluations and safety monitoring to understand the effects of nitrate supplementation on lung disease-related exercise limitations.
CONDITIONS
Official Title
Effects of Drinking Beetroot Juice on Exercise Performance in Patients With Fibrotic Interstitial Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with idiopathic pulmonary fibrosis, fibrotic nonspecific interstitial pneumonia, chronic hypersensitivity pneumonitis, or unclassifiable ILD matching these diagnoses
- Presence of fibrosis on lung CT scan showing honeycombing, reticulation, or traction bronchiectasis
- Oxygen saturation of 92% or higher at rest on room air by pulse oximetry
- Clinically stable with no worsening symptoms for at least 6 weeks prior
- Able to read and write fluently in English
You will not qualify if you...
- Contraindications to exercise testing such as significant cardiovascular, musculoskeletal, or neurological disease
- Other major lung or systemic diseases that could reduce exercise capacity or oxygen levels
- Forced vital capacity (FVC) less than 50% predicted or diffusing capacity of the lungs for carbon monoxide (DLCO) less than 25%
- Use of prednisone over 10 mg daily for more than 2 weeks within 3 months before study start
- Presence of a cardiac pacemaker or any metal or electronic implants inside the body
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Trial Site Locations
Total: 2 locations
1
Providence Health Care - St. Paul's Hosptial
Vancouver, British Columbia, Canada, V6Z 1Y6
Actively Recruiting
2
Vancouver Coastal Health
Vancouver, Canada, V5Z 1M9
Actively Recruiting
Research Team
O
Olivia Ferguson, MSc
D
Dhillon Satvir, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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