Actively Recruiting
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Led by Yale University · Updated on 2026-03-19
256
Participants Needed
1
Research Sites
188 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regulatory scenarios within products where flavor availability is either menthol and tobacco/unflavored available or tobacco/unflavored only available, and nicotine concentration is either higher (5% e-cig, 6mg pouch) or lower (2.4% e-cig, 3mg pouch). Participants will return for bi-weekly research visits (in person or remote videocall) to complete measures for study aims. Participants will complete a final follow-up at Week 6 to assess maintenance of cigarette reduction and willingness to continue using products once they are no longer provided. The investigators expect to observe which products and constituents lead to greater smoking reduction.
CONDITIONS
Official Title
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years of age or older
- Able to read and understand English
- Currently smoking cigarettes, confirmed by biochemical testing
You will not qualify if you...
- Currently using smoking cessation medications such as nicotine replacement therapy, bupropion, or varenicline
- Currently pregnant or breastfeeding
- Having a significant current medical or psychiatric condition
- Known allergy or sensitivity to propylene glycol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
Research Team
L
Lisa M. Fucito, PhD
CONTACT
K
Krysten W Bold, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here