Actively Recruiting
Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis
Led by University of Aarhus · Updated on 2026-02-18
150
Participants Needed
2
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of Aarhus
Lead Sponsor
A
Aarhus University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The EDUEX trial will determine whether the addition of progressive resistance training (PRT) to a patient education program (EDU) will improve clinical outcomes in patients with hip OA. In a subsample, the effect of PRT on the articular cartilage and other structures of the hip joint is investigated. In this subsample, a comprehensive assessment of possible mechanisms underlying the effects of exercise on pain and function is undertaken. The EduEx trial will be a multicentre, stratified (by site), block randomized (allocation 1:1), controlled, parallel-group superiority trial. 150 people with hip OA will be recruited from hospitals, physiotherapy clinics, social media and newspapers. Participants will be randomized to PRT and EDU or EDU alone. All 150 participants will be included in the clinical evaluation study (CLIN). The last 40 participants randomized to PRT+EDU and to EDU, respectively, will also be included in the mechanistic (MECH) evaluation study (n=80), by being asked to participate in additional outcome assessments. The primary endpoint will be the 12 months follow-up for both the CLIN and MECH study, while a secondary endpoint will be the 3-month follow-up.
CONDITIONS
Official Title
Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically diagnosed with hip osteoarthritis according to NICE criteria
- X-ray confirmation of hip osteoarthritis with Kellgren Lawrence score 2 or 3 in one or both hips
- Not scheduled for total hip replacement surgery within the next 12 months
- Experience hip pain daily of at least 3 out of 10 on a pain scale during the past 14 days
- Age 45 years or older
- Able to read and speak Danish adequately
You will not qualify if you...
- Having other health conditions significantly affecting hip function or tissue degeneration (rheumatic, neurological, mental, or other)
- Surgery on lower limbs within 6 months before joining the study
- Body mass index (BMI) over 40
- Pregnant
- Engaged in resistance exercise for lower limbs exceeding 12 sessions in the last 6 months or 6 sessions in the last 3 months
- Claustrophobia or inability to tolerate a whole-body MRI scan
- Presence of metallic implants from waist to above the knee
- Having pacemakers or medical devices not approved for MRI
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Aarhus University
Aarhus C, Denmark, 8000
Not Yet Recruiting
2
Aarhus University Hospital
Aarhus N, Denmark, 8200
Actively Recruiting
Research Team
T
Troels Kjeldsen, MSc
CONTACT
T
Thomas Frydendal, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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