Actively Recruiting
Effects of Education and Progressive Resistance Training Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis
Led by University of Aarhus · Updated on 2026-02-18
150
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Aarhus
Lead Sponsor
A
Aarhus University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether adding progressive resistance training (PRT) to a patient education program (EDU) can improve outcomes for people with hip osteoarthritis (OA). This multicenter trial will recruit 150 adults aged 45 and older with hip OA to compare the combination of PRT and EDU against EDU alone. A subgroup of 80 participants will also have detailed assessments of hip joint tissues to explore how exercise affects pain and function. Participants will be randomly assigned to either a 3-month supervised PRT program followed by 9 months of unsupervised training with booster sessions plus three EDU sessions, or to EDU alone with three education sessions. The PRT involves two weekly 60-minute group exercise sessions focusing on hip and knee muscles. EDU sessions provide disease-specific information and support self-management. The study includes a clinical evaluation of all participants and a mechanistic evaluation in the subgroup with additional MRI scans. Participants will be assessed at baseline, 3 months, and 12 months, with the main outcomes measured at 12 months. These include changes in hip function using the Hip Disability and Osteoarthritis Outcome Score (HOOS) and hip cartilage health via MRI. Secondary assessments involve pain, quality of life, physical function tests, and MRI scoring of joint features. Data will be collected through questionnaires, physical tests, and imaging, with monitoring of adherence to exercise and education sessions throughout the year-long study.
CONDITIONS
Brief Title
Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically diagnosed with hip osteoarthritis according to NICE criteria
- Radiographic confirmation with Kellgren Lawrence score of 2 or 3 in one or both hips
- Not scheduled for total hip replacement within 12 months
- Hip pain every day of at least 3 out of 10 on a numerical rating scale during the last 14 days
- Age 45 years or older
- Adequate written and spoken Danish ability
You will not qualify if you...
- Comorbidities affecting hip function or tissue degeneration (rheumatic, neurological, mental, or other)
- Surgery in lower extremities within 6 months prior to inclusion
- Body mass index (BMI) greater than 40
- Pregnancy
- Resistance exercise for lower extremities exceeding 12 sessions over last 6 months or 6 sessions over last 3 months
- Claustrophobia or inability to tolerate whole body MRI scanner
- Metallic implants from waist to just above the knee
- Pacemaker or other non-MRI approved medical devices
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete baseline assessments before being randomized to one of two groups: progressive resistance training plus education (PRT+EDU) or education alone (EDU).
1 visit (in-person)
Duration - 3 months of supervised training followed by 9 months of unsupervised exercise
Participants in the PRT+EDU group attend supervised group-based progressive resistance training sessions twice weekly for 12 weeks and participate in three education sessions. After 12 weeks, they continue unsupervised exercise with booster sessions. Participants in the EDU group attend the same three education sessions without the exercise program.
2 supervised exercise sessions per week for 3 months plus 3 education sessions, then 8 booster exercise sessions over 9 months
Duration - 12 months
Participants complete follow-up assessments to measure clinical and physiological outcomes at 3 months and 12 months after starting the intervention.
2 visits at 3 months and 12 months (in-person)
Trial Site Locations
Total: 2 locations
1
Aarhus University
Aarhus C, Denmark, 8000
Not Yet Recruiting
2
Aarhus University Hospital
Aarhus N, Denmark, 8200
Actively Recruiting
Research Team
T
Troels Kjeldsen, MSc
T
Thomas Frydendal, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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