Study Comparing Combined Education and Progressive Resistance Training Versus Education Alone in Adults with Hip Osteoarthritis

What this Trial Is About

Researchers are evaluating whether adding progressive resistance training PRT to a patient education program EDU can improve outcomes for people with hip osteoarthritis OA. This multicenter trial will recruit 150 adults aged 45 and older with hip OA to compare the combination of PRT and EDU against EDU alone. A subgroup of 80 participants will also have detailed assessments of hip joint tissues to explore how exercise affects pain and function. Participants will be randomly assigned to either a 3-month supervised PRT program followed by 9 months of unsupervised training with booster sessions plus three EDU sessions, or to EDU alone with three education sessions. The PRT involves two weekly 60-minute group exercise sessions focusing on hip and knee muscles. EDU sessions provide disease-specific information and support self-management. The study includes a clinical evaluation of all participants and a mechanistic evaluation in the subgroup with additional MRI scans. Participants will be assessed at baseline, 3 months, and 12 months, with the main outcomes measured at 12 months. These include changes in hip function using the Hip Disability and Osteoarthritis Outcome Score HOOS and hip cartilage health via MRI. Secondary assessments involve pain, quality of life, physical function tests, and MRI scoring of joint features. Data will be collected through questionnaires, physical tests, and imaging, with monitoring of adherence to exercise and education sessions throughout the year-long study.

Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis