Actively Recruiting
Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Development (PERMICA)
Led by Poitiers University Hospital · Updated on 2025-02-13
200
Participants Needed
1
Research Sites
469 weeks
Total Duration
On this page
Sponsors
P
Poitiers University Hospital
Lead Sponsor
U
University of Poitiers - Laboratoire Ecologie et Biologie des Interactions (EBI) - UMR CNRS 7267
Collaborating Sponsor
AI-Summary
What this Trial Is About
Colorectal cancer is the third most common cancer worldwide, yet it was the second leading cause of cancer-related deaths in 2020. The average French population faces a colorectal cancer risk partly linked to lifestyle factors. The majority of colorectal cancer cases (approximately 85%) are not caused by hereditary mutations. Environmental factors, such as lifestyle or diet (notably through endocrine disruptors), can affect the gut microbiota (a collection of microorganisms - bacteria, viruses, parasites, and fungi - residing in the intestinal environment) and lead to disturbances in its composition, referred to as dysbiosis. While the mechanisms underlying dysbiosis associated with colorectal cancer remain poorly understood, the involvement of certain ingested substances, known as xenobiotics, is increasingly suspected, including endocrine disruptors. Among the most common endocrine disruptors found in water and food are parabens and phthalates, which will be examined in detail in this study. These substances may be directly involved in the development of colorectal cancer and in response to its treatment. The main objective of this studie is to characterize the relationship between colorectal cancer diagnosis, activity/composition of the gut microbiota, and patients' exposure to selected endocrine disruptors, particularly parabens and phthalates.
CONDITIONS
Official Title
Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Development (PERMICA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled endoscopy during the inclusion visit or within 18 months following this consultation
- Signed consent from the patient after clear and fair information about the study is provided
- Patient is free of guardianship, curatorship, or dependency
- Patient is covered by a social security system or through a third party
You will not qualify if you...
- Patients receiving treatment for chronic inflammatory bowel disease
- Patients with hereditary colorectal cancer
- Use of antibiotics, probiotics, or prebiotics within four weeks prior to stool sample collection
- Patients who have undergone neoadjuvant chemotherapy or radiotherapy
- Patients who have had previous surgical resection
- Patients under enhanced protection: minors, individuals deprived of liberty by judicial or administrative decision, individuals residing in healthcare or social institutions, and adults under legal protection
- Pregnant and/or breastfeeding women
- Use of antibiotics, probiotics, or prebiotics before stool collection during the study
- Endoscopy not performed within 18 months following inclusion
- Failure to send or receive stool samples
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU de Poitiers
Poitiers, France, 86000
Actively Recruiting
Research Team
V
Violaine RANDRIAN, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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