Actively Recruiting
Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals
Led by University Hospital, Gentofte, Copenhagen · Updated on 2025-09-08
16
Participants Needed
2
Research Sites
36 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The present study investigates the postprandial role of endogenous glucose-dependent insulinotropic polypeptide (GIP) on cardiovascular haemodynamics, hormone responses, and hypotensive symptoms during a tilt test.
CONDITIONS
Official Title
Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 40 years
- Body mass index (BMI) between 18.5 and 29.9 kg/m2
- Provided informed consent
You will not qualify if you...
- Allergy or intolerance to ingredients in the mixed meal
- History of orthostatic hypotension, postural orthostatic tachycardia syndrome, or other autonomic dysfunction
- Anaemia with hemoglobin below normal range (<7.3 mmol/L for women, <8.3 mmol/L for men)
- Kidney disease with estimated glomerular filtration rate (eGFR) <90 ml/min/1.73 m2
- Known liver disease or elevated plasma alanine aminotransferase (ALT) over three times the upper limit of normal
- Treatment with antihypertensive drugs
- Treatment with GLP-1 receptor agonists
- Treatment with serotonin and noradrenalin reuptake inhibitors or treatment within two weeks before first experimental day
- Use of any ongoing medication that may interfere with participation
- Any physical or psychological condition interfering with participation, including acute or chronic illnesses
- Any disease or treatment that might endanger safety during the trial
- Alcohol or drug abuse
- Pregnancy or breastfeeding
- Participation in another clinical trial during the study period
- Mental incapacity, language barriers, or unwillingness to comply with trial requirements
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Center for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark, 2900
Not Yet Recruiting
2
Center for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark, 2900
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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