Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial.
Danilyn M Angeles, Danilo S Boskovic, John C Tan...
https://pubmed.ncbi.nlm.nih.gov/32103160Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID06692400
The Impact of Endotracheal Suctioning on Pain, Hypoxia, and Oxidative Stress Biomarkers in Intubated Adult ICU Patients: A Controlled Trial
Led by Loma Linda University · Updated on 2025-05-21
110
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether endotracheal tube (ETT) suctioning increases pain and causes stress in adult ICU patients who are intubated and on ventilators. The study aims to measure pain levels using the Critical-Care Pain Observation Tool (CPOT) and to assess changes in blood markers related to stress and low oxygen, such as hypoxanthine, xanthine, and uric acid. Participants with diagnoses like flu, pneumonia, COVID, or sepsis will be included to better understand how suctioning affects these critically ill patients. Participants will be randomly assigned to one of two groups: those who receive routine ETT suctioning and those who do not undergo suctioning during the observation period. Pain will be measured before and after suctioning, and blood samples will be collected at three specific times: 5 minutes before, 5 minutes after, and 30 minutes after suctioning. The procedure will be part of normal care for intubated patients. During the study, researchers will collect demographic information from medical records and monitor pain using the CPOT scale. Blood samples from arterial lines will be analyzed to detect changes in stress and oxygen deprivation markers. The primary outcomes focus on changes in pain scores and serum markers from baseline to 30 minutes after suctioning. This study helps improve pain management for ICU patients who cannot communicate their discomfort. The trial is expected to run until April 2026.
CONDITIONS
Brief Title
The Effects of Endotracheal Suctioning on Pain and Serum Markers
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older
- Current diagnosis of flu, pneumonia, COVID, or sepsis
- Intubated and receiving mechanical ventilation
- Have arterial lines placed
- Require endotracheal suctioning as part of their care
You will not qualify if you...
- Patients receiving neuromuscular blocking agents
- Contraindications for blood draws such as hemoglobin levels below 8.0 g/dL
- Patients who are Jehovah's Witnesses
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Observation
Duration - Duration of ICU stay during mechanical ventilation
Participants who undergo routine care are observed to assess pain levels and serum markers related to endotracheal suctioning.
Assessments occur at baseline and 30 minutes after suctioning
Trial Site Locations
Total: 1 location
1
Loma Linda University Medical Center Troesh Medical Campus
Loma Linda, California, United States, 92354
Actively Recruiting
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Research Team
B
Briana Carr, PhD(c), BSN, RN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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