Actively Recruiting
Effects of Environmental Fungal Exposure on Bronchial Asthma, Allergic Bronchopulmonary Aspergillosis (ABPA), and Bronchiectasis
Led by First Affiliated Hospital of Ningbo University · Updated on 2026-01-02
125
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective, observational study involving adults aged 18 to 80 years who have clinical diagnoses of bronchial asthma, allergic bronchopulmonary aspergillosis (ABPA), bronchiectasis, as well as healthy individuals. The study aims to understand the effects of environmental fungal exposure on these respiratory conditions, grouping asthma patients by control status based on GINA guidelines. It records detailed baseline information including disease history, smoking, previous attacks, hospitalizations, long-term medications, and lifestyle factors like indoor humidity and pet ownership. Participants undergo various assessments at enrollment, including sputum collection (with sputum induction for asthma ABPA), pulmonary function and bronchodilator tests, FeNO measurement for asthma ABPA, blood tests, and allergen detection. Environmental dust samples are taken from indoor and outdoor locations and air conditioner surfaces, with temperature, humidity, and particulate matter recorded. Advanced techniques are used to detect fungi in sputum and dust, and markers related to asthma symptoms are measured. Follow-up occurs after six months to document symptom changes, acute exacerbations, and prognosis. During the study, researchers evaluate fungal presence in respiratory samples and the environment, lung function measures, frequency and severity of exacerbations, emergency visits, hospitalizations, medication use, respiratory failure events, and quality of life scores. Questionnaires assess asthma control and bronchiectasis treatment outcomes. The study carefully monitors participant health over six months to explore how fungal exposure impacts these respiratory diseases.
CONDITIONS
Brief Title
Effects of Environmental Fungal Exposure on Bronchial Asthma, ABPA and Bronchiectasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old, any gender or race
- No history of asthma, ABPA, bronchiectasis, or other chronic respiratory diseases
- No history of allergic diseases such as allergic rhinitis, eczema, or food allergies
- Normal or near-normal lung function
- Blood tests show normal levels of inflammatory and immune cells
- Normal or near-normal allergen-specific IgE levels to common allergens such as dust mites, pet hair, cockroaches, mold, and pollen
You will not qualify if you...
- Diagnosed with bronchial asthma, ABPA, bronchiectasis, or other respiratory diseases like COPD, tuberculosis, pulmonary embolism, lung cancer, pneumothorax, hemoptysis, pulmonary hypertension, or interstitial lung disease
- Serious systemic diseases including recent or active heart attack, stroke, severe hypertension, arrhythmia, heart failure, aortic aneurysm, liver or kidney failure, or blood disorders
- Use of systemic antibiotics, antifungal drugs, immunosuppressants, cytotoxic agents, or hormones within 4 weeks before enrollment
- Any contraindications for induced sputum testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline assessments including respiratory and environmental fungal exposure measurements, lung function tests, and evaluation of respiratory health status.
1 baseline visit (in-person)
Duration - 6 months
Participants are monitored for respiratory health outcomes and acute exacerbations over time to observe effects of environmental fungal exposure.
Follow-up assessments at 6 months (in-person)
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Recruiting
Ningbo, Zhejiang, China, 315010
Actively Recruiting
Research Team
C
Chao Cao
S
Shiyi He
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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