Actively Recruiting
Effects of Environmental Fungal Exposure on Bronchial Asthma, ABPA and Bronchiectasis
Led by First Affiliated Hospital of Ningbo University · Updated on 2026-01-02
125
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective, observational study of patients aged 18-80 years with clinical diagnosis of bronchial asthma, allergic bronchopulmonary aspergillosis (ABPA), bronchiectasis and healthy subjects. Among them, the bronchial asthma group will be divided into asthma control group, asthma partial control group and asthma uncontrolled group according to the GINA asthma control classification. Record the baseline information of the subjects in detail, including basic information, disease course, smoking, previous acute attacks and hospitalizations, long-term medication, etc. (including the frequency, dose and duration of ICS use, antifungal drug type, dose, duration of use, and course of treatment), and evaluate and record environmental factors (such as indoor).Humidity, temperature, ventilation, pet keeping, plant planting, etc.) and other lifestyle factors that may affect disease control and fungal exposure. The patient's disease status was assessed using questionnaire scores. Sputum samples were taken at the time of enrollment.Set (asthma ABPA group uses sputum induction), pulmonary function test and bronchodilator test, FeNO measurement (asthma ABPA group only), blood routine test, Aspergillus-specific IgE and IgG detection, total immunoglobulin IgE, allergen detection, etc. Dust was collected indoors (bedrooms), outdoor (balconies) and on the surface of air conditioners or fans (if applicable) in the subject's living environment, and environmental data such as ambient temperature, humidity, and particulate matter concentration were recorded. 18S rRNA technology was used for sputum and dust fungus detection, and ELISA was used for asthmatitis symptomatic markers, which assess the impact of fungal infections on the disease. Follow-up for each subject 6 months, 6 months after enrollment, the patient's symptom changes, acute exacerbations/exacerbations, and prognosis were recorded, and relevant questionnaire scores were completed.
CONDITIONS
Official Title
Effects of Environmental Fungal Exposure on Bronchial Asthma, ABPA and Bronchiectasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old
- No history of asthma, ABPA, or other chronic respiratory diseases
- No history of allergic diseases such as allergic rhinitis, eczema, or food allergies
- Normal or near normal pulmonary function
- Normal ranges in blood routine tests, including high sensitivity C-reactive protein, white blood cells, neutrophils, lymphocytes, and monocytes
- Normal or near normal IgE levels for common allergens like dust mites, cat hair, dog hair, cockroaches, mold, and pollen
You will not qualify if you...
- Having bronchial asthma, ABPA, bronchiectasis, or other respiratory diseases such as chronic obstructive pulmonary disease, active pulmonary tuberculosis, pulmonary embolism, lung cancer, pneumothorax, hemoptysis, pulmonary arterial hypertension, or interstitial lung disease
- Having serious systemic diseases such as myocardial infarction, stroke, hypertensive crisis or refractory hypertension, severe arrhythmia, heart failure, aortic aneurysm, liver failure, renal failure, or hematological disorders
- Use of systemic antibiotics, antifungal drugs, immunosuppressants, cytotoxic agents, or hormones within 4 weeks prior to enrollment
- Any contraindications for induced sputum testing
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Recruiting
Ningbo, Zhejiang, China, 315010
Actively Recruiting
Research Team
C
Chao Cao
CONTACT
S
Shiyi He
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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