Actively Recruiting
Comparison of Preoperative and Intraoperative Erector Spinae Plane Block Effects on Opioid Use, Anesthetic Use, and Hemodynamics in Lumbar Disc Herniation Surgeries
Led by Ankara Ataturk Sanatorium Training and Research Hospital · Updated on 2025-09-18
60
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lumbar disc herniation (LDH) is a common spine disorder often treated surgically using methods like discectomy, microdiscectomy, or stabilization. This research evaluates how different timing of erector spinae plane block (ESPB), a regional anesthesia technique, affects opioid use, anesthetic consumption, and hemodynamic stability during LDH surgeries. The study aims to find ways to reduce opioid side effects, improve pain control, and lower healthcare costs related to anesthesia and analgesia. Participants undergoing LDH surgery will be randomly assigned to receive ESPB either before surgery (preoperative) or during surgery (intraoperative). Both methods involve injecting local anesthetic guided by ultrasound to numb nerves around the spine. Patients will receive standard general anesthesia with sevoflurane and opioids, and postoperative pain management includes intravenous morphine via patient-controlled analgesia and other pain medications. The study compares the effects of preoperative versus intraoperative ESPB on drug use and patient stability. During the study, researchers will monitor vital signs such as blood pressure, heart rate, oxygen saturation, and anesthetic depth at multiple time points before, during, and after surgery. Pain levels will be measured using a 100-point visual analog scale at rest and during movement up to 48 hours post-surgery. Opioid consumption, additional pain medication needs, and side effects like nausea, dizziness, and respiratory issues will also be recorded. The trial will enroll 60 adults aged 18 to 75 undergoing LDH surgery and follows them through the immediate postoperative period to assess outcomes.
CONDITIONS
Brief Title
Effects of Erector Spinae Plane Block on Opioid Consumption, Anesthetic Consumption and Hemodynamics in Lumbar Disc Herniation Surgeries.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- American Society of Anesthesiologists (ASA) score of I, II, or III
- Body mass index (BMI) between 18 and 40 kg/m2
- Scheduled for lumbar disc herniation surgery under general anesthesia
- Surgery planned at 1 to 3 lumbar levels
- Provided informed consent to participate
You will not qualify if you...
- Severe cardiovascular disease
- Coagulation disorders
- Allergy to anesthetic or analgesic drugs used in the study
- Infection at the injection site for the nerve block
- Severe renal failure, gastrointestinal ulceration, or severe asthma preventing standard analgesia
- Previous lumbar disc herniation surgery at the same spinal level
- Planned surgery involving more than 3 spinal levels
- ASA score of 4 or higher
- Planned use of total intravenous anesthesia (TIVA)
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery (before operation)
Participants assigned to the preoperative group receive bilateral ultrasound-guided erector spinae plane block after sedation and before surgery, followed by a 30-minute wait for the block to take effect before going to the operating room.
1 visit (in-person)
Duration - During surgery
Participants assigned to the intraoperative group receive erector spinae plane block performed by the neurosurgeon after lumbar disc herniation repair during surgery.
1 visit (in-person)
Duration - Up to several hours on day of surgery
All participants undergo lumbar disc herniation surgery under general anesthesia with standard multimodal analgesia applied during and immediately after the procedure.
1 visit (in-person)
Duration - 48 hours post-surgery
Participants receive standard postoperative analgesia and pain management with assessments of pain scores and opioid consumption at multiple timepoints through 48 hours after surgery.
Multiple assessments at postoperative 1st, 2nd, 4th, 8th, 16th, 24th, 36th, and 48th hours
Trial Site Locations
Total: 1 location
1
Ankara Atatürk Sanatorium Training and Research Hospital
Ankara, Turkey (Türkiye)
Actively Recruiting
Research Team
H
Hatice Karabulut
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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