Actively Recruiting
Effects of Esketamine Combined With Dexmedetomidine on Postoperative Sleep Quality
Led by Peking University Shenzhen Hospital · Updated on 2025-12-05
96
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. Eligible patients are randomly divided into experimental and control groups； 2. The experimental group is given esketamine combined with dexmedetomidine，while the control group is given normal saline； 3. The patients' sleep, pain, and cognition are followed up after surgery.
CONDITIONS
Official Title
Effects of Esketamine Combined With Dexmedetomidine on Postoperative Sleep Quality
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age ≥ 65 years old
- Undergoing hip fracture surgery with neuraxial anesthesia
- Signed informed consent
You will not qualify if you...
- ASA classification of Class V or higher
- Contraindications to neuraxial anesthesia such as coagulation dysfunction, thrombocytopenia, neuraxial mass, or puncture site infection
- Allergies or contraindications to esketamine (including intracranial aneurysms, hyperthyroidism, glaucoma)
- Allergies or contraindications to dexmedetomidine
- Severe cardiovascular diseases including sick sinus syndrome, severe sinus bradycardia (heart rate < 50 beats/min), atrioventricular block grade II or above without pacemaker, unstable angina, severe valvular heart disease, severe arrhythmia, severe macrovascular disease with NYHA class III
- Obstructive sleep apnea syndrome with STOP-BANG score over 3
- Severe liver or kidney failure (Child-Pugh score III, creatinine clearance < 35 mL/min, preoperative dialysis)
- Pre-existing delirium, dementia, moderate to severe cognitive dysfunction, or psychiatric disorders preventing communication and cooperation with investigators
AI-Screening
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Trial Site Locations
Total: 1 location
1
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
Actively Recruiting
Research Team
T
Tao Luo, MD,PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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