Actively Recruiting
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
Led by Beijing Tiantan Hospital · Updated on 2024-08-05
150
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Esketamine is an antagonist of N-methyl-d-aspartate (NMDA) receptor different from other gamma-aminobutyric acid (GABA) receptor agonists. Recent studies showed that subanesthetic doses of ketamine not only deepen anesthesia but also accelerate recovery from isoflurane anesthesia in mice. It is necessary to verify if it applies to human. Besides inducing behavioral unresponsiveness, an optimal and important goal of general anesthesia is to prevent connected consciousness. The results of many studies support the conclusion that anesthesia-related unconsciousness is a consistent functional disconnection of lateral frontoparietal networks.The goal of this clinical trial is to learn if subanaesthetic doses of esketamine works to accelerate the recovery of consciousness from propofol anesthesia. It will also learn about the change of brain network when administrated the esketamine during propofol anesthesia. The main questions it aims to answer are: 1. Does subanaesthetic doses of esketamine can accelerate recovery from propofol anaesthesia? 2. What will happen to brain network connection after different doses of esketamine during propofol anesthesia?
CONDITIONS
Official Title
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged from 18 years to 50 years
- Patients scheduled for elective operative hysteroscopy
- Willing to sign informed consent
You will not qualify if you...
- Contraindications of propofol and esketamine
- Contraindications for EEG
- ASA score of III or higher
- BMI greater than or equal to 30 kg/m2 or less than 18 kg/m2
- MMSE scale score below normal
- Alcohol or drug abuse
- Untreated or under-treated hypertension, hyperthyroidism, risk of increased intracranial pressure, audio-visual impairment, history of psychiatric disorders or neurological diseases, malignant tumors or other major diseases
- Use of neurological drugs or drugs interacting with propofol and esketamine in the past 2 weeks
- Pregnant and lactating women
- Operation duration shorter than 15 minutes or longer than 60 minutes
AI-Screening
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Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
Y
Yang Li, Master
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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