Actively Recruiting
Effects of Exercise on Dystonia Pathophysiology
Led by University of Florida · Updated on 2025-07-28
56
Participants Needed
1
Research Sites
272 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia in response to exercise training.
CONDITIONS
Official Title
Effects of Exercise on Dystonia Pathophysiology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients have predominantly focal cervical dystonia confirmed by a movement disorders specialist following Movement Disorders Society criteria
- Moderate disease severity
- Age between 30 and 85 years
- Able to tolerate exercise sessions
- Report suboptimal benefits despite maximally tolerated botulinum toxin injections and/or oral pharmacological therapy for neck muscles
You will not qualify if you...
- Currently participating in another structured exercise program or receiving regular physical or occupational therapy
- Significant pain, spondylosis, or active arthritis
- Failed the Physical Activity Readiness Questionnaire
- Significant cognitive impairment
- Have implanted electrical devices such as cardiac pacemakers, deep brain stimulators, neurostimulators, or metallic clips making MRI or TMS unsafe
- Active seizure disorder or claustrophobia preventing MRI or TMS participation
- Pregnancy or positive pregnancy test for females of childbearing potential at screening and follow-up visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32611
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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