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The Effects of Acute and Chronic Exercise on the Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients
Led by Mayo Clinic · Updated on 2026-04-09
70
Participants Needed
2
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how short-term (acute) and long-term (chronic) exercise affects immune function in patients with indolent non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). Many newly diagnosed CLL patients have early-stage disease that does not require immediate treatment but still experience immune system dysfunction, which increases their risk of serious infections and secondary cancers. This study aims to determine if exercise can improve immune health, delay disease progression, and reduce treatment side effects in these patients. The study includes several parts: initially, participants undergo health assessments including measurements of vital signs, lung function tests, cardiopulmonary exercise testing (CPET), blood sample collection, and possibly DEXA scans. CLL patients participate in a 12-week aerobic exercise program and repeat assessments afterward. Patients with indolent NHL are randomized to either usual care or the same exercise program with similar assessments before and after the intervention. An advanced AI system is being developed to optimize exercise training and compare its effects on quality of life, cancer side effects, and physical fitness. Participants will be assessed through physical tests such as hand grip strength, chest pass power, leg strength, and a 6-minute walk test. Blood samples and lung tests help monitor immune cell counts and function. After completing the exercise or usual care programs, patients will be followed every six months or annually for three years to track immune changes, disease progression, and treatment needs. The main outcomes measured are changes in circulating immune cells and their function at baseline and after up to 12 weeks of intervention.
CONDITIONS
Brief Title
The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English speaking
- Between the ages of 18 and 80
- Histologically confirmed diagnosis of indolent non-Hodgkin lymphoma (NHL) for participation in Aim 2 (CLL/SLL only), Aim 3 and 4 (indolent NHL), and Aim 5 (indolent NHL)
You will not qualify if you...
- Healthy participants in Aim 1 with known cardiovascular or pulmonary disease (e.g., heart disease, coronary artery disease, COPD, asthma)
- Participants with orthopedic or musculoskeletal limitations that restrict exercise ability
- Current or former smokers
- Indolent NHL patients receiving treatment must have at least 8 weeks of planned treatment remaining
- Patients who have already received treatment must be at least 6 months post-treatment and have no planned treatments during the 12-week intervention
- Participants prior to treatment must have no scheduled treatments during participation
- Individuals with uncontrolled hypertension or cardiac illness
- Participants not approved by their oncologist to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 week
Participants undergo measurements of height, weight, vital signs, lung function testing (spirometry), cardiopulmonary exercise testing (CPET), blood sample collection, and may undergo a DEXA scan. Some patients also complete muscular strength and functional endurance tests.
1 to 2 visits depending on assigned assessments
Duration - 12 weeks
Participants assigned to the exercise group complete a 12-week semi-supervised aerobic based training program.
Weekly visits for up to 12 weeks
Duration - 1 week
Participants repeat baseline assessments including measurements of vital signs, lung function testing, exercise testing, blood sample collection, and possibly DEXA scan and physical performance testing to evaluate the effects of the exercise program.
1 to 2 visits depending on assigned assessments
Duration - 12 weeks
Participants receiving usual care are observed alongside those in the exercise program for comparison.
No additional study visits beyond routine care
Duration - Up to 3 years
After completing the intervention, participants are followed up every 6 months or annually for up to 3 years to monitor health status and long-term effects.
Visits every 6 months or annually
Trial Site Locations
Total: 2 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
C
Courtney Wheatley-Guy, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
5
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