Study on How Aerobic Exercise and Daytime Sleep Affect Brain Training and Functional Abilities in Adults With Multiple Sclerosis

What this Trial Is About

Researchers are studying individuals aged 18 to 70 with relapsing-remitting Multiple Sclerosis MS to understand how aerobic exercise and sleep affect motor skill learning and functional abilities. This project explores how activities like cycling on an ergometer bike and taking naps or overnight sleep may improve brain and muscle coordination, measured by complex hand motor tasks and brain-muscle activity tests. The study also looks at how disease activity and fatigue influence these effects. Participants will take part in both a proof-of-concept and a longer-term study. They will perform hand motor tasks while wearing sensors to measure brain and muscle activity. After these tasks, participants will be randomly assigned to one of three groups 20 minutes of aerobic exercise on a bike, a 30-minute nap in a quiet room, or a resting control period. The study sessions are spread over several days with breaks of two weeks to three months between blocks. During the study, participants will undergo various tests including brain and muscle activity recordings, sleep monitoring, and physical fitness assessments. Researchers will measure motor skill learning, brain activity, and muscle function across multiple experiment days. Sleep quality and physical fitness will also be tracked. The study includes detailed monitoring of participants sleep patterns and physical responses to exercise to understand the training effects in MS rehabilitation.

Effects of Exercise and Sleep on Motor Learning and Functional Abilities in Multiple Sclerosis