Study on How a Supervised Exercise Program Affects Thoracic Aortic Aneurysm Size and Blood Pressure Control in Adults

What this Trial Is About

Researchers are studying the effects of a supervised exercise program on patients with non-surgical ascending thoracic aortic aneurysm ATAA. The study aims to understand how exercise impacts blood pressure, muscle strength, aerobic capacity, and aneurysm size. This prospective, randomized study compares these outcomes in an exercise group versus a control group, addressing the unknown influence of physical activity on aneurysm progression and blood pressure in this population. Participants in the exercise group will follow a 24-week supervised program involving high-intensity interval training on a cycle ergometer and strength training three times per week. Sessions last about 60 minutes, with blood pressure and heart rate monitored throughout. The control group continues usual daily activities and receives consultations with a kinesiologist at baseline, 3 months, and 6 months for lifestyle advice. Both groups undergo measurements and tests at baseline, 3 months, and 6 months. Participants will have various assessments including blood pressure monitoring over 24 hours, cardiopulmonary exercise tests to measure aerobic capacity VO2max, muscle strength evaluations, body composition analysis, and CT scans to monitor aneurysm size. Physical activity will be tracked using a wearable armband. The primary outcome is aneurysm diameter at 3 months. Safety and progression are closely monitored over the study period, which lasts at least 6 months from the start of intervention.

Effects of Exercise on Thoracic Aneurysms