Actively Recruiting
The Effects of Exogenous Ketones on Cognitive Function
Led by University of Alabama at Birmingham · Updated on 2026-01-07
45
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the acute effects of exogenous ketone monoester (KME) supplementation on cognitive function in three groups of adults aged 19-55 years: (1) obese, sedentary individuals; (2) lean, sedentary individuals; and (3) lean individuals who engage in regular physical activity (e.g., collegiate or amateur athletes). The main questions it aims to answer are to: * Assess the effects of acute KME supplementation versus placebo on cognitive, sensorimotor, and functional outcomes within groups. * Compare cognitive performance across the three groups. The primary outcome is cognitive performance assessed using the NIH Toolbox Cognition Battery. Secondary Outcomes include sensorimotor performance, measured using the Senaptec Sensory System, and driving performance, assessed with a driving simulator.
CONDITIONS
Official Title
The Effects of Exogenous Ketones on Cognitive Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 19-55 years
- BMI 30-40 for the obese group or 18-25 for lean and athlete groups
- Sedentary status defined as less than 2 hours per week of structured physical activity for obese and lean groups
- Active athlete status defined as 5 or more days per week of structured physical activity for the athlete group
You will not qualify if you...
- Diagnosed neurological conditions such as Parkinson's disease, multiple sclerosis, schizophrenia, muscular dystrophy, stroke, or cerebral palsy
- History of seizures
- Use of medications for diabetes, mood disorders, or attention disorders
- Pregnant or breastfeeding
- Current or recent use (within 1 month) of exogenous ketone supplements or adherence to a ketogenic diet
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
916 Building
Birmingham, Alabama, United States, 35205
Actively Recruiting
Research Team
S
Sarah K Sweatt, PhD
CONTACT
E
Eric Plaisance
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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