Actively Recruiting
Potential Effects of Fibres Combined With Probiotics on Uric Acid and Related Metabolites in an ex Vivo Fermentation Model
Led by Örebro University, Sweden · Updated on 2025-08-12
15
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
Ö
Örebro University, Sweden
Lead Sponsor
U
University of Copenhagen
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how probiotics combined with dietary fibers affect uric acid metabolism in people with hyperuricaemia, a condition where uric acid levels are elevated in the blood. The study involves collecting blood and stool samples to understand whether these combinations can help the gut microbiota break down uric acid. This observational study is sponsored by Örebro University, Sweden, and aims to explore potential effects in laboratory fermentation models using stool samples. Participants will first provide a blood sample to confirm hyperuricaemia. Those with elevated urate levels will complete questionnaires and receive materials for stool collection during a second visit. In a third visit, participants provide their stool samples, which will be tested in the lab with different beta-glucan fibers combined with two probiotic strains. These tests will examine how the combination influences urate and related metabolites in an ex vivo fermentation model. During the study, participants will attend three visits for sample collection and data gathering. Researchers will analyze the stool fermentation supernatants after 24 hours to measure urate levels, metabolites related to urate, and short-chain fatty acids. The study monitors adherence to dietary restrictions regarding probiotics and other supplements until stool collection. Participation lasts through these three visits, concluding with laboratory analyses that assess the gut microbiota's response to the tested fibers and probiotics.
CONDITIONS
Brief Title
Effects of Fibres Combined With Probiotics on Uric Acid in an ex Vivo Fermentation Model
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent prior to any study-related procedures
- Age 18-80 years old
- BMI range 18.5-35 kg/m2
- Blood uric acid above 0.36 mmol/L (6 mg/dl)
- Willing to abstain from regular consumption of probiotic supplements or foods containing probiotic bacteria until stool sample collection
- Willing to abstain from regular consumption of supplements and medications known to affect gastrointestinal function or inflammation until stool sample collection
You will not qualify if you...
- Diagnosis of type 1 and/or type 2 diabetes
- Diagnosed inflammatory bowel disease (IBD)
- Current diagnosis of psychiatric disease or syndromes
- Current diagnosis of neurodegenerative disease
- Current pregnancy or breastfeeding
- History of complicated gastrointestinal surgery
- Use of systemic antibiotics or steroid medication within 4 months prior to inclusion
- Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) in the last 2 months
- Consumption of NSAIDs within 3 days before sample collection
- Use of probiotic supplements within 4 weeks before study start
- Any condition or medication that could interfere with study outcomes as decided by the principal investigator
- Starting any new medication or treatment that could affect study participation or analysis after inclusion until stool collection
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 weeks
Participants with high blood uric acid provide stool samples for laboratory faecal fermentation tests to study the effects of probiotics and dietary fibers.
2 visits (in-person)
Duration - 24 hours
Stool samples are used in faecal fermentation experiments to test different fibres combined with probiotics.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Örebro University
Örebro, Sweden
Actively Recruiting
Research Team
J
Julia König, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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