Actively Recruiting
Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults
Led by University of Connecticut · Updated on 2025-07-28
28
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how consuming grape powder affects immune system markers, inflammation, and metabolism in healthy adults aged 50 to 75. This study focuses on understanding how grapes, which contain nutrients and antioxidants like resveratrol and quercetin, may influence immune function changes that occur with aging. The study is sponsored by the University of Connecticut and aims to explore the impact of grape consumption on immune health in middle- and older-aged individuals. Participants will consume a freeze-dried grape powder or a control powder that tastes the same but lacks grape compounds. Each powder is taken daily as a beverage for 4 weeks, with a total study duration of 13 weeks. During this time, participants must avoid eating grapes and certain other foods rich in antioxidants and polyphenols. The study includes a randomized, double-blind design comparing the effects of the grape powder to the control. Throughout the 13 weeks, participants will attend 7 visits lasting about 6.25 hours in total. They will provide blood samples, complete surveys about diet, physical activity, and medical history, and have their body weight measured. Researchers will measure immune markers such as the concentration of lipopolysaccharide-induced interleukin-1 beta secreted from immune cells. The study monitors health and immune responses to understand the effects of grape powder consumption in healthy aging adults.
CONDITIONS
Brief Title
Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 50-75 years old at time of screening
- Body mass index (BMI) between 18.5 and less than 30 kg/m2
- Willing to consume grape and control powder during study periods
- Agree to avoid eating grapes and certain other polyphenol-rich foods and beverages during the study
- Do not meet any exclusion criteria
You will not qualify if you...
- Younger than 50 or older than 75 years
- BMI less than 18.5 or 30 and above, or body weight less than 110 pounds
- Experienced more than 10% weight change in the past 4 weeks
- Elevated fasting glucose higher than 126 mg/dL or triglycerides above 500 mg/dL
- History of diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, severe autoimmune, inflammatory or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
- Allergy to grapes or any ingredients in the study powders
- Implanted medical device preventing body composition measurement by bioelectrical impedance
- Currently taking lipid-lowering, glucose-regulating, anti-inflammatory, blood clotting medications, long-term antibiotics in the last 3 months, or active use of probiotics
- Active smoker
Research Team
C
Catherine J Andersen, PhD, RDN
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