Actively Recruiting
Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults
Led by University of Connecticut · Updated on 2025-07-28
28
Participants Needed
1
Research Sites
109 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, and metabolism that are known to change with aging. Grapes contain several nutrients and antioxidant polyphenols such as resveratrol, quercetin, vitamin K and fiber, which are known to promote heart and immune health. However, the effects of grapes on altering immune profiles within the context of aging is not well understood. Therefore, this study will explore how daily grape consumption impacts certain markers of immunity in healthy middle- and older-aged adults. The main study procedures include consumption of a freeze-dried grape powder and control powder (which tastes the same but has none of the grape compounds that are being studied) mixed with water as a beverage on a daily basis for 4 weeks each. The investigators will additionally ask that participants avoid eating grapes and certain other antioxidant/grape-related foods and beverages throughout the 13-week study. Participants will additionally be asked to complete surveys about their diet, physical activity, and medical history, as well as provide blood samples and body weight measures throughout the course of the study. Participation in the study is expected to last about 6.25 hours over the course of 13 weeks and will include 7 visits.
CONDITIONS
Official Title
Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 50-75 years old at time of screening
- Body mass index (BMI) 18.5 to less than 30 kg/m2
- Willing to consume grape and control powder during study periods
- Willing to avoid eating grapes and certain other polyphenol-rich foods and beverages during the study
- Do not meet any exclusion criteria
You will not qualify if you...
- Younger than 50 years or older than 75 years
- BMI less than 18.5 or 30 kg/m2 and above, or body weight less than 110 pounds
- More than 10% weight change in past 4 weeks
- Elevated fasting glucose over 126 mg/dL or triglycerides over 500 mg/dL
- History of diabetes mellitus, coronary heart disease, stroke, kidney or liver disease, cancer, eating disorders, severe or relapsing autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, pregnancy, or lactation
- Allergy to grapes or ingredients in the study powders
- Implanted medical device or health condition preventing body composition measurement by bioelectrical impedance
- Currently taking lipid-lowering, glucose-regulating, anti-inflammatory, or blood clotting medications, long-term antibiotics in last 3 months, or active probiotics use
- Active smoker
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Nutritional Sciences
Storrs, Connecticut, United States, 06269
Actively Recruiting
Research Team
C
Catherine J Andersen, PhD, RDN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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