Actively Recruiting
Effects of Frontopolar TMS in Alcohol Craving
Led by Goethe University · Updated on 2026-01-22
34
Participants Needed
2
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this interventional study is to learn if continuous theta burst stimulation (cTBS) applied over the left frontopolar cortex can reduce psychological, physiological, and neurobiological markers of alcohol craving in patients with alcohol dependence (AD). The main questions it aims to answer are: * Does cTBS over the left frontopolar cortex reduce psychological and physiological measures of alcohol craving in individuals with AD? * Are baseline structural and functional brain connectivity patterns associated with individual differences in cTBS-induced changes in craving? The participants will: * Receive cTBS over the left frontopolar cortex using an accelerated protocol comprising 15 TMS-sessions on five consecutive days * Undergo psychological and physiological assessments of alcohol craving before and after the TMS intervention * Complete magnetic resonance imaging (MRI) sessions to assess baseline brain structural and functional connectivity This study aims to advance the understanding of the neurophysiological mechanisms underlying craving in AD and the identification of potential biomarkers for predicting psychological and physiological craving reductions.
CONDITIONS
Official Title
Effects of Frontopolar TMS in Alcohol Craving
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18-65
- ICD-10 diagnosis of alcohol dependence
- Ability to give consent
- Sinus rhythm in ECG
You will not qualify if you...
- Current psychotic symptoms in patients with psychotic disorders (F20, F23, F10.5)
- Contraindication against TMS or MRI
- Severe neurological disorders such as epilepsy, stroke, neuroinflammatory disorders (e.g., multiple sclerosis). A history of seizures only in the context of alcohol withdrawal does not represent a contraindication, unless the seizure happened in the last 3 weeks before study inclusion
- Acute withdrawal symptoms (CIWA-Ar > 5)
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie Universitätsklinikum Frankfurt, Goethe-Universität
Frankfurt am Main, Hesse, Germany, 60528
Actively Recruiting
2
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie Universitätsklinikum Frankfurt, Goethe-Universität
Frankfurt am Main, Hesse, Germany, 60528
Actively Recruiting
Research Team
F
Franka Timm, M.Sc.
CONTACT
J
Jonathan Repple, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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