Actively Recruiting
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.
Led by Prairie View A&M University · Updated on 2026-04-16
20
Participants Needed
1
Research Sites
6 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to understand how gallotannin-rich (GT-rich) mangoes can reduce the inflammatory markers in obese individuals in vitro. The study will also seek to explore how gallotannins are metabolized in the gut microbiome. The main questions the research aims to answer are: * What is the impact of GT extract from mango and Lactiplantibacillus pentosus supplementation on inflammatory biomarkers in obese individuals? * Does the combination of GTs and L. pentosus exhibit synergistic effects in modulating specific microbial taxa associated with obesity and inflammation compared to either intervention alone? * Does genetic variation among individuals with obesity account for the ability to metabolize gallotannins? Researchers will compare the effects of GT extract from mango juice, a combination of GT-rich extract, and L. pentosus probiotic supplement on samples (stool) provided by obese individuals, to samples provided by a lean control group to see if gallotannins and gallotannins + probiotic supplementation reduce inflammation in obesity. Participants will * Be grouped into 4 treatment groups 1. Mango juice only 2. Mango + L. pentosus 3. L. pentosus only 4. Control (lean individuals) * Visit sample collection site one time during the study (week 1)
CONDITIONS
Official Title
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 to 55 years, male or female
- Lean participants with BMI between 18 and 24.9 kg/m2
- Obese participants with BMI between 30 and 40 kg/m2
- Participants must be screened and confirmed for BMI through height and weight measurements
You will not qualify if you...
- History of acute cardiac events, stroke, or cancer
- Recurrent hospitalizations or drug treatment for listed conditions within 6 months before study
- Alcohol or substance abuse
- Use of medications for type 2 diabetes or related diseases
- Smoking more than 1 pack per week
- History of seizures within the last 6 months
- Liver, intestinal, or renal dysfunction
- Pregnancy or lactation
- Allergy to gallotannins or mango
- History of hepatitis B, hepatitis C, or HIV
- Use of systemic antibiotics within 1 month before screening
- Participation in other interventional research studies
- Intake of herbal dietary supplements
AI-Screening
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Trial Site Locations
Total: 1 location
1
Collaborative Agricultural Research Center
Prairie View, Texas, United States, 77446
Actively Recruiting
Research Team
J
Janet Antwi, Doctor of Philosophy
CONTACT
O
Obed Akwaa Harrison, Doctor Philosophy
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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