Actively Recruiting
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Led by Adrian Vella · Updated on 2025-06-04
20
Participants Needed
1
Research Sites
211 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.
CONDITIONS
Official Title
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Weight-stable adults with type 2 diabetes
- Body mass index (BMI) of 28 or higher
- Diabetes managed by diet alone or oral medications
You will not qualify if you...
- History of upper abdominal surgery such as gastric banding, pyloroplasty, or vagotomy
- Active systemic illness or cancer
- Symptomatic macrovascular or microvascular disease
- Contraindications to MRI, including metal implants or claustrophobia
- Hematocrit less than 35%
- Thyroid stimulating hormone (TSH) less than 0.4 or greater than 5.5
- Consumption of more than 2 alcoholic drinks per day or more than 14 per week, or a positive AUDIT questionnaire
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
J
Jeanette Laugen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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